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pyrimidine nucleotide biosynthetic process

Known as: pyrimidine nucleotide formation, pyrimidine nucleotide biosynthesis, pyrimidine nucleotide anabolism 
The chemical reactions and pathways resulting in the formation of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base… 
National Institutes of Health

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2 relations
negative regulation of pyrimidine nucleotide biosynthetic processpositive regulation of pyrimidine nucleotide biosynthetic process

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2006
Review
2006
The role of multidrug resistance efflux transporters in antifolate resistance and folate homeostasis.
Highly Cited
2005
Highly Cited
2005
The crystal structure of Pyrococcus furiosus UMP kinase provides insight into catalysis and regulation in microbial pyrimidine nucleotide biosynthesis.
Review
2004
Review
2004
Uridine phosophorylase: an important enzyme in pyrimidine metabolism and fluoropyrimidine activation.
Uridine phosphorylase (UPase) is an enzyme that can convert uridine to uracil. Upon the availability of substrates, UPase can… 
Review
2000
Review
2000
Immunosuppressive drugs: the first 50 years and a glance forward.
Highly Cited
1999
Highly Cited
1999
p53 inhibits entry into mitosis when DNA synthesis is blocked
Human and mouse fibroblasts with normal p53 fail to enter mitosis when DNA synthesis is blocked by aphidicolin or hydroxyurea… 
Highly Cited
1996
Highly Cited
1996
Two activities of the immunosuppressive metabolite of leflunomide, A77 1726. Inhibition of pyrimidine nucleotide synthesis and protein tyrosine phosphorylation.
Highly Cited
1989
Highly Cited
1989
The effect of glutamine concentration on the activity of carbamoyl-phosphate synthase II and on the incorporation of [3H]thymidine into DNA in rat mesenteric lymphocytes stimulated by…
The maximum catalytic activities of carbamoyl-phosphate synthase II, a limiting enzyme for pyrimidine nucleotide synthesis, are… 
Highly Cited
1987
Highly Cited
1987
Effects of ciprofloxacin on eucaryotic pyrimidine nucleotide biosynthesis and cell growth
Several of the new 4-quinolones significantly increase the incorporation of [3H]thymidine into the DNA of mitogen-stimulated… 
Highly Cited
1976
Highly Cited
1976
Antitumor activity of N-(phosphonacetyl)-L-aspartic acid, a transition-state inhibitor of aspartate transcarbamylase.
N-(Phosphonacetyl)-L-aspartate (PALA) is an analog of the transition state for the aspartate transcarbamylase reaction and has… 
Highly Cited
1976
Highly Cited
1976
Stable mutants of mammalian cells that overproduce the first three enzymes of pyrimidine nucleotide biosynthesis
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