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SUMMARY The antigenicity of several well established Moloney virus-induced transplantable leukemias was studied. Resistance was developed by pretreatment of isologous mice with x-radiated tumorExpand
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Animal toxicology for early clinical trials with anticancer agents.
This analysis was carried out to assess quantitative and qualitative relationships between animal and human toxicology data with anticancer drugs. Among 21 chemotherapeutic agents, one-sixth LD10 inExpand
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Hematopoietic recovery after large doses of cyclophosphamide: correlation of proliferative state with sensitivity.
Hematological recovery after a large dose of cyclophosphamide was characterized by early rapid recovery of marrow stem cells (colony-forming assay), followed successively by recovery of circulatingExpand
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Antitumor activity of N-(phosphonacetyl)-L-aspartic acid, a transition-state inhibitor of aspartate transcarbamylase.
N-(Phosphonacetyl)-L-aspartate (PALA) is an analog of the transition state for the aspartate transcarbamylase reaction and has been reported previously to be a potent and specific inhibitor of deExpand
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The effect of nicotinamide on incorporation in vivo of formate-C14.
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Drug-mediated antigenic changes in murine leukemia cells: antagonistic effects of quinacrine, an antimutagenic compound.
Because the antigenic changes occurring after in vivo treatment of murine lymphoma cells with 5-(3,3-dimethyl-1-triazenyl)-1H-imidazole-4-carboxamide (DTIC) were suggested to result from DTIC-inducedExpand
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In vitro generation of a highly immunogenic subline of L1210 leukemia following exposure to 5-(3,3'-dimethyl-1-triazeno)imidazole-4-carboxamide.
Strong and heritable increase of immunogenicity of L1210 Ha leukemia has been obtained in vitro following multiple treatments with 5-(3,3'-dimethyl-1-triazeno)imidazole-4-carboxamide (DTIC),Expand
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Therapeutic and pharmacological studies of tetrachloro(d,l-trans)1,2-diaminocyclohexane platinum (IV) (tetraplatin), a new platinum analogue.
Tetrachloro(d,l-trans)1,2-diaminocyclohexane platinum (IV) (tetraplatin), a new platinum analogue, showed greater therapeutic efficacy after i.p. administration than eitherExpand
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18F-5-Fluorouridine, a new probe for measuring the proliferation of tissue in vivo.
(1) Increased metabolic trapping of labeled fluorouridine reflects the interaction of three parameters in rapidly proliferating tissues: increased rates of intracellular phosphorylation, increasedExpand
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