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pumitepa

Known as: 2-dimethylamino-6-diethyleneiminophosphamido-7-methylpurine, Fopurin, phopurinum 
A thiotepa derivative with potential antineoplastic alkylating activity. Although the exact mechanism of action of pumitepa has yet to be fully… 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (3)

Antineoplastic Agents, AlkylatingAziridinesPurines

Papers overview

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2004
2004
Mutagenic and antimutagenic properties of bemitil
Complex research of the genetic activity of a new 2-mercaptobenzimidazole derivative bemythyl has shown that the drug failed to… 
1994
1994
Characteristics of cycle-dependent effects of antitumor drugs of the dispirotreperazine series, spirobromine and prospidine
Antitumor drugs are divided into two main groups according to the nature of the dependence of the effects that they cause on the… 
1990
1990
Persistence of cytogenetic damage induced by alkylating antineoplastic drug phopurinum in human lymphocytes in vivo and in vitro.
1989
1989
[Effect of natural human leukocyte interferon on cell cycle kinetics, the frequency of sister chromatid exchanges and chromosome aberrations in fopurin-treated human lymphocytes].
Natural human leukocyte interferon (50 IU/ml), added to human lymphocytes for 24 hour incubation time, increased the background… 
1989
1989
In vitro interaction between two antineoplastic drugs--phopurinum and interferon alpha 2.
Induction of sister chromatid exchanges (SCEs) and chromosome aberrations (CAs) by two antineoplastic drugs--phopurinum (2… 
1989
1989
[Effect of natural human leukocyte interferon on cell cycle kinetics, the frequency of sister chromatid exchanges and chromosome aberrations in fopurin-treated human lymphocytes].
Natural human leukocyte interferon (50 IU/ml), added to human lymphocytes for 24 hour incubation time, increased the background… 
1981
1981
Pharmacokinetics of [3H]fopurin in rats with sarcoma M-1
Our original antileukemia preparation fopurin -2-dimethylamino~6~methyleneimino-6-diethyleneimido-phosphamido-7-methyl groups… 
1980
1980
Investigation of the immunotropic activity of antitumor preparations fotrin and fopurin and their drug forms
Th~ investigations were conducted on female hybrid mice (CBA x C57BL/6)F, weighing 18-22 g. Sheep erythrocytes, administered in a… 
1980
1980
Investigation of the pharmacokinetics of [32P] fopurin in the bodies of mice with lympholeukemia L-1210
V. Z. Gorkin, Adv. Pharmaco!. Chemother., ii, 1-50 (1973). V. Z. Gorkin, in: Monoamine Oxidase and its Inhibition, Amsterdam… 
1977
1977
Synthesis of the antineoplastic preparation fopurin, labeled with the phosphorus isotope32P, and study of its metabolism in the animal organism
Phosphorus pentaehloride, containing the phosphorus isotope ~2p with specific activity 12.5 BCi/mg, was used as the initial… 
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