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Oxygen radical-mediated mutagenic effect of asbestos on human lymphocytes: suppression by oxygen radical scavengers.
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Some causes of inter-laboratory variation in the results of comet assay.
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Verapamil contributes to the clastogenic effects of acrylamide, cyclophosphamide, and dioxidine on somatic cells of BALB/C and C57BL/6 mice.
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[Effect of antiasthenic drug ladasten on the level of cytokines and behavior in experimental model of anxious depression in C57BL/6 male mice].
TLDR
The antiasthenic drug ladasten limits development of the anxious depressive state and suppresses the level of pro-inflammatory cytokines IL-6, IL-17 and IL-4, and is suggested as a possible candidate drug for adjuvant therapy of depressive disorders.
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Summary of Clinical Laboratory Studies Performed During Preclinical Safety Evaluation of Medicinal Products (Part II: Biochemical and Pathomorphological Studies)
TLDR
The aim of the paper was to summarise the methodology of biochemical and pathomorphological studies based on the experience obtained in the Drug Toxicology Laboratory of the Federal State Budgetary Institute «Zakusov Institute of Pharmacology» when conducting chronic toxicity studies.
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[Antimutagenic and antiteratogenic properties of afobazole].
Experiments of mice and rats showed the ability of afobazole (1, 10, and 100 mg/kg, p.o.) upon single, 5-day combined, and 5-day preliminary administration to prevent or significantly decrease the…
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Afobazole Protects Rats Exposed to Peat Smoke In Utero
TLDR
Female outbred albino rats were daily subjected to forced inhalations of peat smoke per se and in combination with oral afobazole (anxiolytic) in doses of 1 and 10 mg/kg on days 1–20 of pregnancy and during the pre- and postnatal periods.
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Correcting Effect of Ladasten on Variations in the Subpopulation Composition of T Lymphocytes in C57Bl/6 Mice on the Experimental Model of an Anxious-Depressive State
TLDR
Administration of Ladasten had a normalizing effect on the relative weights of study organs and subpopulation composition of T cells in immunocompetent organs, which returned to the control level.
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Antiallergenic activity of birch bark dry extract with at least 70% betulin content
TLDR
Studies on models of pseudoallergenic reaction to concanavalin A in mice and carragenan-induced paw edema in rats showed that the anti-inflammatory action of BBDE is comparable with that of Suprastin and Claritin and is more pronounced than the effect of betulin.
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[Genotypic, sex and age differences in appearance of the mutagenic effect of cyclophosphamide in mice].
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