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The study of in vivo occupancy of benzodiazepine receptors in rat hippocampus and cerebellum indicates that premazepam reaches… Expand 1. General introduction 425 1.1. Factors affecting in vivo activity 426 1.1.1. Affinity for benzodiazapine receptors 426 1.l.2… Expand Compounds of different chemical classes, with affinity for central benzodiazepine receptors, were investigated for effects on… Expand The in‐vitro binding characteristics of three different ligands ([3H]Ro 15–1788, [3H]Ro 5–4864 and [3H]flunitrazepam) and the… Expand Arousal of the electrocorticogram induced by intermittent footshocks in sleeping rats was originally developed to detect hypnotic… Expand Pharmacological studies of premazepam in animals predicted antianxiety activity without sedation and, in combination with… Expand Premazepam (PRZ) in vitro competitively displaced 3H-diazepam (DIA), 3H-flunitrazepam (FLU) and 3H-RO 15-1788 from their binding… Expand A study of the disposition and metabolism of premazepam, 3,7-dihydro-5-phenyl-6,7-dimethyl-pyrrole[3,4-e][1,4]diazepin-2-(1 H… Expand Premazepam, a pyrrolodiazepine with potential anxiolytic properties, behaves as a partial antagonist to diazepam in animal tests… Expand