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6-(Alkylamino)-3-aryl-1,2,4-triazolo[3,4-a]phthalazines. A new class of benzodiazepine receptor ligands.
Differences from the classical benzodiazepines in the animal tests indicate that 80 may have some selective anxiolytic activity, and this compound was inactive in counteracting the strychnine and maximal electroshock induced convulsions and in the "aggressive monkey" model.
Clinical Safety of SonoVue™, a New Contrast Agent for Ultrasound Imaging, in Healthy Volunteers and in Patients with Chronic Obstructive Pulmonary Disease
SonoVue showed a good safety profile both in healthy subjects and in patients with COPD, and no statistically significant differences between SonoVue™ and placebo were observed in mean forced expiratory volume, forced vital capacity, or forced midexpiratory flow levels.
Differential binding in vitro to glucocorticoid receptors of deflazacort and prednisolone.
In vivo stereospecific [3H]spiperone binding in rat brain: characteristics, regional distribution, kinetics and pharmacological properties.
Pharmacokinetics and tissue distribution of iomeprol in animals.
Neurotolerability of nonionic X-ray contrast media. The role of chemotoxicity.
- F. Luzzani, A. Morisetti, S. Bussi, P. Tirone, C. de Haën
- Medicine, BiologyInvestigative radiology
- 1 June 1996
Neurotoxicity of monomer or dimer contrast media depends more on chemical structure characteristics other than hydrophilicity than on the physicochemical characteristics of their solutions.
General pharmacology in experimental animals of gadobenate dimeglumine (MultiHance), a new magnetic resonance imaging contrast agent.
- P. Tirone, M. Castano, C. de Haën
- Medicine, BiologyJournal of computer assisted tomography
- 1 November 1999
The clinical use of gadobenate dimeglumine as an intravascular magnetic resonance imaging contrast agent is strongly supported by the good tolerability of the product in healthy and pathological animal models.
Correlation of biliary epomediol-beta-glucuronide levels with bile flow enhancement in the rat.
In female Wistar rats, epomediol (Clesidren) (30-300 mg/kg p.o.) induced a dose-dependent increase of bile flow and a concomitant enhancement in both unchanged drug and its mono-beta-glucuronide (M…
Influence of day of pregnancy on rat placental, uterine, and ovarian prostaglandin synthesis and metabolism.
Synthesis and metabolism of prostaglandins in reproductive tissues of the gravid rat were studied from the time of post-implantation to just prior to parturition. Rat placental prostaglandin…