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Distress vocalization in rat pups. A simple screening method for anxiolytic drugs.
  • C. Gardner
  • Medicine
  • Journal of pharmacological methods
  • 1 November 1985
A method is described for reproducible measurement of ultrasonic vocalization induced by tail-holding stress in rat pups. The anxiolytic benzodiazepines, chlordiazepoxide, diazepam, and CL 218872,Expand
High-throughput crystallization: polymorphs, salts, co-crystals and solvates of pharmaceutical solids.
TLDR
The impact of form diversity encompasses issues of stability and bioavailability, as well as development considerations such as process definition, formulation design, patent protection and regulatory control. Expand
Combined use of crystalline salt forms and precipitation inhibitors to improve oral absorption of celecoxib from solid oral formulations.
TLDR
Formulations of crystal forms having high energy (a 'spring'), thus transiently increasing solubility in aqueous solution relative to the free acid, combined with excipients functioning as precipitation inhibitors ('parachutes') were shown to provide both enhanced dissolution and high oral bioavailability. Expand
Inhibition of ultrasonic distress vocalizations in rat pups by chlordiazepoxide and diazepam
TLDR
Wistar rat pups emit ultrasonic distress cries when placed on a cold plate or when held by the tail, and it is suggested that the benzodiazepines may reduce the sound via their anxiolytic action. Expand
Drugs as materials: valuing physical form in drug discovery
TLDR
The challenge of pharmaceutical materials discovery is discussed, and strategies for addressing the characterization and evaluation of physico-chemical and material properties in the drug discovery and development process are suggested. Expand
Pharmacological characterisation of a modified social interaction model of anxiety in the rat.
Social interaction (SI) between two unfamiliar male rats in a dimly lit, familiar environment has been investigated as a model of anxiety, where novelty of the partner remains as the principalExpand
Effect of particle size and food on gastric residence time of non‐disintegrating solids in beagle dogs
TLDR
The gastric residence times of various sizes of radio‐opaque particles and tablets were measured in beagle dogs by X‐ray, both in the fasted state and after a single meal, and changes in intragastric pH were monitored with a radiotelemetric pH sensor. Expand
Hypothermia as an indicator of the acute effects of lipopolysaccharides : Comparison with serum levels of IL1β, IL6 and TNFα
TLDR
Hypothermia is a useful parameter for indicating the strength of the acute effects of LPS and is compared with the induction of serum levels of IL1β, TNFα and IL6, which indicates that the cytokines studied here play a causative role in hypothermia. Expand
Hypothermia as an indicator of the acute effects of lipopolysaccharides: comparison with serum levels of IL1 beta, IL6 and TNF alpha.
TLDR
Hypothermia is a useful parameter for indicating the strength of the acute effects of LPS, and was compared with the induction of serum levels of IL1 beta, TNF alpha and IL6 to determine whether or not the cytokines studied here play a causative role in hypothermia. Expand
The behavioural effects of RU 24969, a suggested 5-HT1 receptor agonist in rodents and the effect on the behaviour of treatment with antidepressants
TLDR
The results obtained are consistent with the view that administration of 5-HT agonists, such as quipazine and 5-methoxy-N,N-dimethyltryptamine, produces behaviour that results from stimulation of both 5- HT1 and5-HT2 receptor populations. Expand
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