A. Assandri

Publications80
h-index13
Citations644
Highly Influential Citations19
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Systemic Absorption of Rifamycin SV MMX Administered as Modified-Release Tablets in Healthy Volunteers
ABSTRACT The new oral 200-mg rifamycin SV MMX modified-release tablets, designed to deliver rifamycin SV directly into the colonic lumen, offer considerable advantages over the existing…
Pharmacokinetics of rifapentine, a new long lasting rifamycin, in the rat, the mouse and the rabbit.
TLDR
In mice and rabbits rifapentine shows a kinetic profile resembling that obtained in rats, whereas in rabbits is metabolized and/or eliminated much more rapidly with a half-life of only 1.8 hours.
Pharmacokinetics and metabolism of deflazacort in the rat, dog, monkey and man.
Local tolerability and pharmacokinetic profile of a new transdermal delivery system, diclofenac hydroxyethylpyrrolidine plaster.
TLDR
The results obtained in the safety studies demonstrate the absence of local skin reactions and of sensitization phenomena, and the kinetic evidence, obtained at the steady-state, reveals a profile typical of a sustained-release formulation.
In vivo stereospecific [3H]spiperone binding in rat brain: characteristics, regional distribution, kinetics and pharmacological properties.
Binding of teicoplanin to human serum albumin
TLDR
The in vitro findings were confirmed by a pharmacokinetic study in volunteers given [14C] teicoplanin i.v., in whom the fraction of teioplanin bound to serum protein ranged between 87.6 and 90.8%.
Pharmacokinetics of [14C]teicoplanin in male rats after single intravenous dose
TLDR
The pharmacokinetic profile of [14C]teicoplanin was studied in male Sprague-Dawley rats given a single 10,000-U/kg intravenous dose and the profile of total 14C in plasma was similar to that of the microbiological activity.
The Immunosuppressor ST1959, a 3,5-Diaryl-S-Triazole Derivative, Inhibits T Cell Activation by Reducing NFAT Nuclear Residency
TLDR
Investigation in a murine model of colitis indicates that the beneficial effects exerted by ST1959 rely upon a decreased local immunological response, and insights are provided into the molecular mechanisms underlying the immunomodulatory activity of ST1959.
Gas chromatography-mass spectrometry determination of etodolac in human plasma following single epicutaneous administration.
A highly sensitive gas chromatographic-mass spectrometric method for the determination of etodolac acid, as methyl ester, in plasma was developed. The feasibility and specificity of the method was…
Visualizing central effects of S-adenosyl-L-methionine (SAMe), a natural molecule with antidepressant properties, by pharmaco-EEG mapping.
TLDR
The pharmaco-EEG findings suggest both inhibitory and excitatory drug effects at the neurophysiological level, underlying the antidepressant properties well-documented in clinical trials.
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