• Publications
  • Influence
Benzodiazepines revisited--will we ever learn?
  • M. Lader
  • Medicine
  • Addiction
  • 1 December 2011
TLDR
A series of adverse effects that continued to cause concern were noted, such as cognitive and psychomotor impairment, and dependence and abuse remain as serious problems despite warnings and guidelines. Expand
Use of psychotropic medication in the general population of France, Germany, Italy, and the United Kingdom.
TLDR
A concomitant physical illness increased the likelihood of using a psychotropic treatment and was a strong predictor of adequate psychotropic dosage. Expand
Efficacy and tolerability of escitalopram in 12‐ and 24‐week treatment of social anxiety disorder: Randomised, double‐blind, placebo‐controlled, fixed‐dose study
TLDR
It is concluded that doses of 5–20 mg escitalopram are effective and well tolerated in the short‐ and long‐term treatment of generalised SAD. Expand
Social phobia: diagnosis and epidemiology, neurobiology and pharmacology, comorbidity and treatment.
TLDR
The first, large scale, placebo-controlled study to assess the efficacy of drug treatment in generalized social phobia has been completed with paroxetine, which was more effective in reducing the symptoms than placebo and was well tolerated. Expand
Causes and Management of Hyponatremia
TLDR
Although hyponatremia can be a serious condition, appropriate measures for the management of at-risk and affected patients will lead to full recovery in most cases. Expand
Do Benzodiazepines Still Deserve a Major Role in The Treatment of Psychiatric Disorders? A Critical Reappraisal
TLDR
A critical appraisal of the current use and role of BZDs in psychiatric disorders and their disadvantages is provided, with specific emphasis on anxiety and affective disorders, sleep disorders, alcohol withdrawal, violent and aggressive behaviours in psychoses, and neuroleptic-induced disorders. Expand
Selective serotonin reuptake inhibitors: meta‐analysis of discontinuation rates
TLDR
There is a significant and clinically important advantage for the SSRIs compared with the TCAs in the acceptability of treatment measured by the number of discontinuations due to side effects reported in published studies. Expand
Physiological and psychological measures in anxious patients.
TLDR
It is concluded that pathological anxiety involves an increase in arousal irrelevant to the task and has a disorganizing rather than a facilitating effect on performance. Expand
Benzodiazepine harm: how can it be reduced?
  • M. Lader
  • Medicine
  • British journal of clinical pharmacology
  • 1 February 2014
The benzodiazepines (BZDs) are anxiolytics, hypnotics, anticonvulsants, muscle‐relaxants and induce anaesthesia. Adverse effects comprise sedation subjectively and cognitive and psychomotorExpand
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