pregabalin

Known as: (S)-3-Isobutyl gaba, (S)-3-(aminomethyl)-5-methylhexanoic acid, S-(+)-3-isobutylgaba 
A 3-isobutyl derivative of gamma-amino butyric acid (GABA) with anti-convulsant, anti-epileptic, anxiolytic, and analgesic activities. Although the… (More)
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
BACKGROUND Despite the enormous success of total knee arthroplasty (TKA), chronic neuropathic pain can develop postoperatively… (More)
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Review
2006
Review
2006
Gabapentin and pregabalin are structurally related compounds with recognized efficacy in the treatment of both epilepsy and… (More)
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Highly Cited
2005
Highly Cited
2005
OBJECTIVE Fibromyalgia syndrome (FMS) is characterized by widespread musculoskeletal pain and lowered pain threshold. Other… (More)
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Highly Cited
2005
Highly Cited
2005
Pregabalin binds with high affinity to the alpha2-delta subunit protein of voltage-gated calcium channels and, thereby, reduces… (More)
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Highly Cited
2005
Highly Cited
2005
BACKGROUND Pregabalin inhibits release of excess excitatory neurotransmitters, presumably by binding to the alpha2-delta subunit… (More)
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Highly Cited
2005
Highly Cited
2005
UNLABELLED This was a 6-week, randomized, double-blind, multicenter study evaluating the efficacy of pregabalin in the treatment… (More)
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Review
2004
Review
2004
Pregabalin is a potent ligand for the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system that… (More)
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Highly Cited
2002
Highly Cited
2002
Gabapentin and pregabalin (S-(+)-3-isobutylgaba) produced concentration-dependent inhibitions of the K(+)-induced [Ca(2+)](i… (More)
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Highly Cited
2001
Highly Cited
2001
Pain intensity is frequently measured on an 11-point pain intensity numerical rating scale (PI-NRS), where 0=no pain and 10=worst… (More)
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Highly Cited
2001
Highly Cited
2001
Pregabalin is an analogue of the inhibitory neurotransmitter gamma-aminobutyric acid. In preclinical models, it has shown… (More)
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