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pregabalin

Known as: (S)-3-Isobutyl gaba, (S)-3-(aminomethyl)-5-methylhexanoic acid, S-(+)-3-isobutylgaba 
A 3-isobutyl derivative of gamma-amino butyric acid (GABA) with anti-convulsant, anti-epileptic, anxiolytic, and analgesic activities. Although the… 
National Institutes of Health

Related topics

Related topics

23 relations

Broader (5)

AminobutyrateAnalgesicsAnti-Anxiety AgentsAnticonvulsants

Narrower (3)

CI 1008LyricaPD 144723
In BloodPregabalin:MCnc:Pt:Ser/Plas:QnPregabalin:PrThr:Pt:Urine:Ord:ScreenPregabalin:SCnc:Pt:Ser/Plas:Qn

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
Effect of oral pregabalin on opioid-induced hyperalgesia in patients undergoing laparo-endoscopic single-site urologic surgery
Background Pregabalin is an antiepileptic drug that is effective for treating postoperative pain, neuropathic pain, anxiety, and… 
2013
2013
Management of painful neuropathies.
2012
2012
Pregabalin in clinical psychiatry and addiction: pros and cons
Pregabalin acts as a presynaptic modulator of excitatory neurotransmitter release, binding to the α²-δ subunit protein of voltage… 
2010
2010
Augmentation with pregabalin in schizophrenia.
Anxiety is a core symptom of schizophrenia that elicits significant subjective burden of disease and contributes to treatment… 
2007
2007
Pregabalin decreases visceral pain and prevents spinal neuronal activation in rats
We read the recent article by Houghton et al ( Gut 2007, Apr 19 [Epub ahead of print]), reporting that pregabalin, a new… 
2007
2007
Alpha-2-delta ligands for singultus (hiccup) treatment: three case reports.
2006
2006
Pre-emptive analgesia and protective premedication. What is the difference?
  • L. Bromley
  • Biomedicine & pharmacotherapy = Biomedecine…
  • 2006
  • Corpus ID: 36352382
Highly Cited
2005
Highly Cited
2005
Pregabalin Drug Interaction Studies: Lack of Effect on the Pharmacokinetics of Carbamazepine, Phenytoin, Lamotrigine, and Valproate in Patients with Partial Epilepsy
Summary:  Purpose: Pregabalin (PGB) is an α2‐δ ligand with demonstrated efficacy in epilepsy, neuropathic pain, and anxiety… 
Highly Cited
2003
Highly Cited
2003
Synthesis of both enantiomers of a P-chirogenic 1,2-bisphospholanoethane ligand via convergent routes and application to rhodium-catalyzed asymmetric hydrogenation of CI-1008 (pregabalin).
Both enantiomers of a P-chirogenic 1,2-bisphospholanoethane ligand are synthesized via two convergent methods. The first method… 
1974
1974
IMMUNOLOGICAL RESPONSES OF MICE TO NATIVE PROTOPLASMIC POLYSACCHARIDE AND LIPOPOLYSACCHARIDE
Functional separation of the two signals involved in stimulating immunological responses was achieved through the judicious use… 
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