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pregabalin

Known as: (S)-3-Isobutyl gaba, (S)-3-(aminomethyl)-5-methylhexanoic acid, S-(+)-3-isobutylgaba 
A 3-isobutyl derivative of gamma-amino butyric acid (GABA) with anti-convulsant, anti-epileptic, anxiolytic, and analgesic activities. Although the… 
National Institutes of Health

Related topics

Related topics

23 relations

Broader (5)

AminobutyrateAnalgesicsAnti-Anxiety AgentsAnticonvulsants

Narrower (3)

CI 1008LyricaPD 144723
In BloodPregabalin:MCnc:Pt:Ser/Plas:QnPregabalin:PrThr:Pt:Urine:Ord:ScreenPregabalin:SCnc:Pt:Ser/Plas:Qn

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
Validation of LC-TOF-MS screening for drugs, metabolites, and collateral compounds in forensic toxicology specimens.
Liquid chromatography time-of-flight mass spectrometry (LC-TOF-MS) analysis provides an expansive technique for identifying many… 
2013
2013
Orofacial sensory changes after streptozotocin-induced diabetes in rats
2012
2012
Pregabalin in clinical psychiatry and addiction: pros and cons
Pregabalin acts as a presynaptic modulator of excitatory neurotransmitter release, binding to the α²-δ subunit protein of voltage… 
2010
2010
Augmentation with pregabalin in schizophrenia.
Anxiety is a core symptom of schizophrenia that elicits significant subjective burden of disease and contributes to treatment… 
Highly Cited
2009
Highly Cited
2009
A Simple Organocatalytic Enantioselective Synthesis of Pregabalin
This paper describes a new procedure for the enantioselective synthesis of the important anticonvulsant drug Pregabalin, which… 
Highly Cited
2009
Highly Cited
2009
Effects of pregabalin on post operative morphine consumption and pain after abdominal hysterectomy with/without salphingo-oophorectomy: a randomized, double-blind trial.
BACKGROUND Achieving post operative pain management is difficult with the use of only opioids analgesia. Multimodal pain… 
2006
2006
Pre-emptive analgesia and protective premedication. What is the difference?
  • L. Bromley
  • Biomedicine & pharmacotherapy = Biomedecine…
  • 2006
  • Corpus ID: 36352382
Highly Cited
2005
Highly Cited
2005
Pregabalin Drug Interaction Studies: Lack of Effect on the Pharmacokinetics of Carbamazepine, Phenytoin, Lamotrigine, and Valproate in Patients with Partial Epilepsy
Summary:  Purpose: Pregabalin (PGB) is an α2‐δ ligand with demonstrated efficacy in epilepsy, neuropathic pain, and anxiety… 
Highly Cited
2003
Highly Cited
2003
Synthesis of both enantiomers of a P-chirogenic 1,2-bisphospholanoethane ligand via convergent routes and application to rhodium-catalyzed asymmetric hydrogenation of CI-1008 (pregabalin).
Both enantiomers of a P-chirogenic 1,2-bisphospholanoethane ligand are synthesized via two convergent methods. The first method… 
1974
1974
IMMUNOLOGICAL RESPONSES OF MICE TO NATIVE PROTOPLASMIC POLYSACCHARIDE AND LIPOPOLYSACCHARIDE
Functional separation of the two signals involved in stimulating immunological responses was achieved through the judicious use… 
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