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Algorithm for neuropathic pain treatment: An evidence based proposal
TLDR
NNT and NNH are currently the best way to assess relative efficacy and safety, but the need for dichotomous data, which may have to be estimated retrospectively for old trials, and the methodological complexity of pooling data from small cross‐over and large parallel group trials, remain as limitations. Expand
EFNS guidelines on pharmacological treatment of neuropathic pain
TLDR
Evaluated trials provide level A evidence for the efficacy of tricyclic antidepressants, gabapentin, pregabalin and opioids, with a large number of class I trials, followed by topical lidocaine and the newer antidepressants venlafaxine and duloxetine. Expand
The evidence for pharmacological treatment of neuropathic pain
TLDR
Large‐scale drug trials that aim to identify possible subgroups of patients who are likely to respond to specific drugs are needed to test the hypothesis that a mechanism‐based classification may help improve treatment of the individual patients. Expand
Efficacy of pharmacological treatments of neuropathic pain: an update and effect related to mechanism of drug action
TLDR
It is concluded that tricyclic antidepressants in optimal doses appear to be the most efficient treatment of neuropathic pain, but some of the other treatments may be important due to their better tolerability. Expand
Electrophysiological and psychophysical quantification of temporal summation in the human nociceptive system
TLDR
The aim of the present study was to investigate whether the nociceptive reflex, evoked by repetitive strong electrical sural nerve stimuli, increased when summation was reported by the volunteers and to determine the threshold for psychophysical summation. Expand
The clinical picture of neuropathic pain.
TLDR
The clinical manifestations of neuronal hyperexcitability due to nervous system lesions is described and a mechanism-based classification has been proposed, which is an attractive approach because it provides a frame for a rationally based therapy of neuropathic pains. Expand
The hypoalgesic effect of tramadol in relation to CYP2D6 *
TLDR
It is concluded that formation of (+)‐M1 by way of CYP2D6 is important for the effect of tramadol on experimental pain. Expand
Symptoms and signs in patients with suspected neuropathic pain
TLDR
Although certain symptoms (touch or cold provoked pain) and signs (brush‐evoked allodynia) are more prominent in patients with definite or possible NP, there is considerable overlap with the clinical presentation of patients with unlikely NP. Expand
Tramadol relieves pain and allodynia in polyneuropathy: a randomised, double-blind, controlled trial
TLDR
It is concluded that tramadol appears to relieve both ongoing pain symptoms and the key neuropathic pain feature allodynia in polyneuropathy. Expand
The postmastectomy pain syndrome: an epidemiological study on the prevalence of chronic pain after surgery for breast cancer
TLDR
Although recent advances in the diagnostic and surgical procedures have reduced the frequency of the more invasive surgical procedures, there still is a considerable risk of developing postmastectomy pain syndrome after treatment of breast cancer. Expand
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