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A Comparison of the Pharmacokinetics and Pharmacodynamics of Pregabalin and Gabapentin
Pregabalin and gabapentin share a similar mechanism of action, inhibiting calcium influx and subsequent release of excitatory neurotransmitters; however, the compounds differ in their pharmacokineticExpand
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Pregabalin for the treatment of postherpetic neuralgia
Objective: To evaluate the efficacy and safety of pregabalin in the treatment of postherpetic neuralgia (PHN). Methods: The authors conducted a multicenter, parallel-group, double-blind,Expand
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Relief of painful diabetic peripheral neuropathy with pregabalin: a randomized, placebo-controlled trial.
UNLABELLED This was a 6-week, randomized, double-blind, multicenter study evaluating the efficacy of pregabalin in the treatment of painful diabetic neuropathy. Two hundred forty-six men and womenExpand
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Disposition of gabapentin (neurontin) in mice, rats, dogs, and monkeys.
Gabapentin, an analog of gamma-aminobutyric acid, exhibits anticonvulsant properties in both animal models and humans. Gabapentin pharmacokinetics was studied in laboratory animals using HPLC andExpand
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Pharmacokinetics of Pregabalin in Subjects with Various Degrees of Renal Function
The objectives of this study were to determine the single‐dose pharmacokinetics of pregabalin in subjects with various degrees of renal function, determine the relationship between pregabalinExpand
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Clinical Pharmacokinetics of Pregabalin in Healthy Volunteers
Pregabalin has shown clinical efficacy for treatment of neuropathic pain syndromes, partial seizures, and anxiety disorders. Five studies in healthy volunteers are performed to investigate single‐Expand
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A Saturable Transport Mechanism in the Intestinal Absorption of Gabapentin Is the Underlying Cause of the Lack of Proportionality Between Increasing Dose and Drug Levels in Plasma
Gabapentin (l-(aminomethyl)cyclohexaneacetic acid) is a neuroprotective agent with antiepileptic properties. The structure is small (molecular weight less than 200), is zwitterionic, and resembles anExpand
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Gabapentin bioavailability: effect of dose and frequency of administration in adult patients with epilepsy
UNLABELLED Gabapentin (GBP) is a non-metabolized antiepileptic drug that is eliminated by renal excretion and displays saturable, dose dependent absorption. The recommended dosing schedule for GBP isExpand
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Effects of Age and Gender on Single‐Dose Pharmacokinetics of Gabapentin
Summary: Purpose: This study was conducted to evaluate the effect of age, age‐related changes in renal function, and gender on the single‐dose pharmacokinetics of orally administered gabapentin (GBP).
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Exposure‐Response Analysis in Patients With Schizophrenia to Assess the Effect of Asenapine on QTc Prolongation
An exposure‐response (E‐R) analysis using linear mixed effects modeling was conducted on data from a thorough QTc trial for asenapine in 148 patients with schizophrenia. In a parallel design,Expand
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