ponatinib

Known as: 3-(2-(imidazo(1,2-b)pyridazin-3-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazin-y-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide, Benzamide, 3-(2-Imidazo(1,2-B)Pyridazin-3-Ylethynyl)-4-Methyl-N-(4-((4-Methyl-1- Piperazinyl)Methyl)-3-(Trifluoromethyl)Phenyl), Ponatinibum 
An orally bioavailable multitargeted receptor tyrosine kinase (RTK) inhibitor with potential antiangiogenic and antineoplastic activities. Ponatinib… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2011-2017
05020112017

Papers overview

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2015
2015
Necroptosis is a form of regulated necrotic cell death mediated by receptor-interacting serine/threonine-protein kinase 1 (RIPK1… (More)
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2015
2015
Drug development for life-threatening diseases is still a process in evolution. In oncology, as drugs have become more targeted… (More)
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Highly Cited
2014
Highly Cited
2014
Ponatinib is the only currently approved tyrosine kinase inhibitor (TKI) that suppresses all BCR-ABL1 single mutants in… (More)
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2014
2014
The presence of acquired multidrug resistance (MDR) is one of the primary impediments to the success of chemotherapy. MDR is… (More)
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Highly Cited
2013
Highly Cited
2013
BACKGROUND Ponatinib is a potent oral tyrosine kinase inhibitor of unmutated and mutated BCR-ABL, including BCR-ABL with the… (More)
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2013
2013
Myeloid and lymphoid malignancies associated with fibroblast growth factor receptor-1 (FGFR1) abnormalities are characterized by… (More)
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2013
2013
Patients with advanced systemic mastocytosis, including mast cell leukemia, have a poor prognosis. In these patients, neoplastic… (More)
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Highly Cited
2012
Highly Cited
2012
BACKGROUND Resistance to tyrosine kinase inhibitors in patients with chronic myeloid leukemia (CML) and Philadelphia chromosome… (More)
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Highly Cited
2012
Highly Cited
2012
Members of the fibroblast growth factor receptor family of kinases (FGFR1-4) are dysregulated in multiple cancers. Ponatinib… (More)
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2012
2012
The treatment of patients with chronic myeloid leukemia (CML) must be ranked as one of the great medical success stories of the… (More)
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