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ponalrestat

Known as: 3-(4-Bromo-2-fluorobenzyl)-3,4-dihydro-4-oxo-1-phthalazineacetic Acid, 3-(4-bromo-2-fluorobenzyl)-3,4-dihydro-4-oxo-3H-phthalazin-1-ylacetic acid 
National Institutes of Health

Related topics

Related topics

5 relations

Broader (3)

Enzyme InhibitorsHypoglycemic AgentsPhthalazines

Narrower (2)

ICI 128436Statil

Papers overview

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2013
2013
Evaluation of the prostaglandin F synthase activity of human and bovine aldo-keto reductases: AKR1A1s complement AKR1B1s as potent PGF synthases.
2003
2003
Up-regulation of aldose reductase by the substrate, methylglyoxal.
1994
1994
Increased resistance to hypoxic conduction block in sciatic nerves of diabetic rats: effects of extracellular glucose concentration and of aldose reductase inhibition.
1992
1992
Dissociation between biochemical and functional effects of the aldose reductase inhibitor, ponalrestat, on peripheral nerve in diabetic rats
1 The aim of the study was to examine the effects in rats of two different doses of the aldose reductase inhibitor, ponalrestat… 
1992
1992
Studies on the biochemical effects of the aldose reductase inhibitor 2,7-difluorospirofluorene-9,5'-imidazolidine-2',4'-dione (Al 1576, HOE 843). Detection of D-glucaric and D-glucuronic acid…
1991
1991
Effects of diabetes on cholinergic transmission in two rat gut preparations.
Highly Cited
1991
Highly Cited
1991
Reduction of Glomerular Hyperfiltration in Normoalbuminuric IDDM Patients by 6 mo of Aldose Reductase Inhibition
Hyperglycemia causes enhanced glucose metabolism by the polyol pathway in tissues not requiring insulin for glucose uptake. It… 
Highly Cited
1990
Highly Cited
1990
Effects of Long-Term Aldose Reductase Inhibition on Development of Experimental Diabetic Neuropathy: Ultrastructural and Morphometric Studies of Sural Nerve in Streptozocin-Induced Diabetic Rats
There is controversy over the efficacy of aldose reductase inhibitors in preventing the development of peripheral nerve lesions… 
1990
1990
Confirmation of lens hydration by Raman spectroscopy.
1989
1989
Myo-inositol normalizes decreased sodium permeability of the blood-brain barrier in streptozotocin diabetes
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