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ICI 128436

Known as: ICI 128,436, ICI-128436 
 
National Institutes of Health

Papers overview

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1995
1995
Vascular endothelial cells, which are polyfunctional, play an important role in the pathogenesis of diabetic complications. The… Expand
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1993
1993
We investigated the effects of glucose on specific D-alpha-tocopherol binding to cultured bovine aortic endothelial cells. Our… Expand
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1991
1991
Increased flux through the polyol pathway mediated by the enzyme aldose reductase may be associated with the development of… Expand
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1988
1988
The hypothesis that sorbitol accumulation could contribute to a reduced erythrocyte deformability in diabetes was investigated… Expand
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1988
1988
The present study examined the effect of the aldose reductase inhibitor Statil (ICI 128436, ICI, Cheshire, U.K.) on the levels of… Expand
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1987
1987
This study was designed to examine the effect of exaggerated polyol-pathway flux on sciatic nerve content of polyols, myo… Expand
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1986
1986
Galactose neuropathy was produced in rats by feeding a diet containing 30% D-galactose. After 12 weeks of galactose ingestion… Expand
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1986
1986
This study measured sugars and polyols, weight/unit length, and slow component-a of axonal transport (SCa) in dorsal root… Expand
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1985
1985
ICI 128,436 (3-(4-bromo-2-fluorobenzyl)-4-oxo-3H-phthalazin-1-ylacetic acid) is a chemically novel, potent inhibitor of aldose… Expand
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1985
1985
This investigation examined the effect of treatment of streptozocin-diabetic rats with the aldose reductase inhibitor "Statil… Expand
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