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ICI 128436

Known as: ICI 128,436, ICI-128436 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

ponalrestat

Papers overview

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1995
1995
Increased transendothelial permeation of albumin by high glucose concentration.
Vascular endothelial cells, which are polyfunctional, play an important role in the pathogenesis of diabetic complications. The… Expand
1993
1993
High glucose reduces specific binding for D-alpha-tocopherol in cultured aortic endothelial cells.
We investigated the effects of glucose on specific D-alpha-tocopherol binding to cultured bovine aortic endothelial cells. Our… Expand
1991
1991
Clinical and Neurophysiological Studies of Aldose Reductase Inhibitor Ponalrestat in Chronic Symptomatic Diabetic Peripheral Neuropathy
Increased flux through the polyol pathway mediated by the enzyme aldose reductase may be associated with the development of… Expand
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1988
1988
Effect of Statil (ICI 128436) on Erythrocyte Viscosity In Vitro
The hypothesis that sorbitol accumulation could contribute to a reduced erythrocyte deformability in diabetes was investigated… Expand
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1988
1988
The effect of aldose reductase inhibitor Statil (ICI 128436) on the glucose over-utilization in kidney of diabetic rats.
The present study examined the effect of the aldose reductase inhibitor Statil (ICI 128436, ICI, Cheshire, U.K.) on the levels of… Expand
1987
1987
Does Galactose Feeding Provide a Valid Model of Consequences of Exaggerated Polyol-Pathway Flux in Peripheral Nerve in Experimental Diabetes?
This study was designed to examine the effect of exaggerated polyol-pathway flux on sciatic nerve content of polyols, myo… Expand
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Highly Cited
1986
Highly Cited
1986
Edema and increased endoneurial sodium in galactose neuropathy Reversal with an aldose reductase inhibitor
Galactose neuropathy was produced in rats by feeding a diet containing 30% D-galactose. After 12 weeks of galactose ingestion… Expand
1986
1986
Slow Component-a of Axonal Transport, Nerve myo-Inositol, and Aldose Reductase Inhibition in Streptozocin-Diabetic Rats
This study measured sugars and polyols, weight/unit length, and slow component-a of axonal transport (SCa) in dorsal root… Expand
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Highly Cited
1985
Highly Cited
1985
Properties of ICI 128,436, a novel aldose reductase inhibitor, and its effects on diabetic complications in the rat.
ICI 128,436 (3-(4-bromo-2-fluorobenzyl)-4-oxo-3H-phthalazin-1-ylacetic acid) is a chemically novel, potent inhibitor of aldose… Expand
1985
1985
Prevention of Defective Axonal Transport in Streptozocin-diabetic Rats by Treatment with “Statil” (ICI 128436), an Aldose Reductase Inhibitor
This investigation examined the effect of treatment of streptozocin-diabetic rats with the aldose reductase inhibitor “Statil… Expand
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