ICI 128436

The coordinated activity of estrogens and epidermal growth factor receptor (EGFR) family agonists represents the main determinant… (More)

Vascular endothelial cells, which are polyfunctional, play an important role in the pathogenesis of diabetic complications. The… (More)

Increased flux through the polyol pathway mediated by the enzyme aldose reductase may be associated with the development of… (More)

The present study examined the effect of the aldose reductase inhibitor Statil (ICI 128436, ICI, Cheshire, U.K.) on the levels of… (More)

The hypothesis that sorbitol accumulation could contribute to a reduced erythrocyte deformability in diabetes was investigated… (More)

The accumulation of polyols has been previously found in renal glomeruli isolated from streptozocin-induced diabetic (STZ-D) rats… (More)

This study was designed to examine the effect of exaggerated polyol-pathway flux on sciatic nerve content of polyols, myo… (More)

Galactose neuropathy was produced in rats by feeding a diet containing 30% D-galactose. After 12 weeks of galactose ingestion… (More)

This investigation examined the effect of treatment of streptozocin-diabetic rats with the aldose reductase inhibitor "Statil… (More)

ICI 128,436 (3-(4-bromo-2-fluorobenzyl)-4-oxo-3H-phthalazin-1-ylacetic acid) is a chemically novel, potent inhibitor of aldose… (More)