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Vascular endothelial cells, which are polyfunctional, play an important role in the pathogenesis of diabetic complications. The… Expand We investigated the effects of glucose on specific D-alpha-tocopherol binding to cultured bovine aortic endothelial cells. Our… Expand Increased flux through the polyol pathway mediated by the enzyme aldose reductase may be associated with the development of… Expand The hypothesis that sorbitol accumulation could contribute to a reduced erythrocyte deformability in diabetes was investigated… Expand The present study examined the effect of the aldose reductase inhibitor Statil (ICI 128436, ICI, Cheshire, U.K.) on the levels of… Expand This study was designed to examine the effect of exaggerated polyol-pathway flux on sciatic nerve content of polyols, myo… Expand Galactose neuropathy was produced in rats by feeding a diet containing 30% D-galactose. After 12 weeks of galactose ingestion… Expand This study measured sugars and polyols, weight/unit length, and slow component-a of axonal transport (SCa) in dorsal root… Expand ICI 128,436 (3-(4-bromo-2-fluorobenzyl)-4-oxo-3H-phthalazin-1-ylacetic acid) is a chemically novel, potent inhibitor of aldose… Expand This investigation examined the effect of treatment of streptozocin-diabetic rats with the aldose reductase inhibitor “Statil… Expand