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Statil

National Institutes of Health

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ponalrestat

Papers overview

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2010
2010
Thiol-disulfide exchanges modulate aldo-keto reductase family 1 member B10 activity and sensitivity to inhibitors.
Highly Cited
2004
Highly Cited
2004
Prevention of sensory disorders in diabetic Sprague-Dawley rats by aldose reductase inhibition or treatment with ciliary neurotrophic factor
Aims/hypothesisSensory neuropathy in diabetic patients frequently presents itself as progressive loss of thermal perception… 
1995
1995
Increased transendothelial permeation of albumin by high glucose concentration.
Highly Cited
1991
Highly Cited
1991
Effect of Insulin and Statil on Aldose Reductase Expression in Diabetic Rats
Tissue accumulation of sorbitol secondary to enhanced polyol-pathway activity is believed to play an important role in the… 
Highly Cited
1990
Highly Cited
1990
Aldehyde and aldose reductases from human placenta. Heterogeneous expression of multiple enzyme forms.
1990
1990
Ponalrestat: a potent and specific inhibitor of aldose reductase.
1990
1990
Inhibition kinetics of human kidney aldose and aldehyde reductases by aldose reductase inhibitors.
1988
1988
Effect of Statil (ICI 128436) on Erythrocyte Viscosity In Vitro
The hypothesis that sorbitol accumulation could contribute to a reduced erythrocyte deformability in diabetes was investigated… 
Highly Cited
1986
Highly Cited
1986
Effect of hyperglycemia on sorbitol and myo-inositol content of cultured rat conceptus: failure of aldose reductase inhibitors to modify myo-inositol depletion and dysmorphogenesis.
1985
1985
Prevention of Defective Axonal Transport in Streptozocin-diabetic Rats by Treatment with “Statil” (ICI 128436), an Aldose Reductase Inhibitor
This investigation examined the effect of treatment of streptozocin-diabetic rats with the aldose reductase inhibitor “Statil… 
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