A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes
- N. Bottini, L. Musumeci, T. Mustelin
- Biology, MedicineNature Genetics
- 7 March 2004
We report that a single-nucleotide polymorphism (SNP) in the gene (PTPN22) encoding the lymphoid protein tyrosine phosphatase (LYP), a suppressor of T-cell activation, is associated with type 1…
The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes
- J. Wenzlau, K. Juhl, J. Hutton
- Biology, MedicineProceedings of the National Academy of Sciences
- 23 October 2007
The combined measurement of ZnT8A, GADA, IA2A, and IAA raised autoimmunity detection rates to 98% at disease onset, a level that approaches that needed to detect prediabetes in a general pediatric population.
Type 1 diabetes: new perspectives on disease pathogenesis and treatment
- M. Atkinson, G. Eisenbarth
- MedicineThe Lancet
- 21 July 2001
Monoclonal antibody to a plasma membrane antigen of neurons.
- G. Eisenbarth, F. Walsh, M. Nirenberg
- BiologyProceedings of the National Academy of Sciences…
- 1 October 1979
Results suggest that the antigen is a complex ganglioside in plasma membranes of retina neuron cell bodies but not axons or dendrites, which suggests that antibody A2B5 cytotoxicity against retina cells is inhibited by a GQ gangliosiside fraction from bovine brain but not by other purifiedgangliosides tested.
International trial of the Edmonton protocol for islet transplantation.
- A. Shapiro, C. Ricordi, J. Lakey
- MedicineNew England Journal of Medicine
- 28 September 2006
Islet transplantation with the use of the Edmonton protocol can successfully restore long-term endogenous insulin production and glycemic stability in subjects with type 1 diabetes mellitus and unstable control, but insulin independence is usually not sustainable.
Type 1 diabetes
- M. Atkinson, G. Eisenbarth, A. Michels
- MedicineThe Lancet
- 4 January 2014
Genetics, pathogenesis and clinical interventions in type 1 diabetes
- J. Bluestone, K. Herold, G. Eisenbarth
- Medicine, BiologyNature
- 1 April 2010
Current progress, the challenges ahead and the new interventions that are being tested to address the unmet need for preventative or curative therapies are described.
Seroconversion to multiple islet autoantibodies and risk of progression to diabetes in children.
- A. Ziegler, M. Rewers, G. Eisenbarth
- Medicine, BiologyJAMA
- 19 June 2013
The majority of children at risk of type 1 diabetes who had multiple islet autoantibody seroconversion progressed to diabetes over the next 15 years, and future prevention studies should focus on this high-risk population.
Type I diabetes mellitus. A chronic autoimmune disease.
- G. Eisenbarth
- Biology, MedicineNew England Journal of Medicine
- 22 May 1986
Evidence has suggested that progressive loss of first-phase insulin secretion precedes diabetes, and immunologic findings have suggested that selection of selected assays for islet-cell antibodies has been defined.
Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice
- M. Nakayama, N. Abiru, G. Eisenbarth
- Biology, MedicineNature
- 12 May 2005
It is suggested that proinsulin is a primary autoantigen of the NOD mouse, and speculate that organ-restricted autoimmune disorders with marked major histocompatibility complex (MHC) restriction of disease are likely to have specificPrimary autoantigens.
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