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plY protein, Streptococcus pneumoniae

Known as: pneumolysin 
National Institutes of Health

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2 relations

Broader (2)

Bacterial ProteinsStreptolysins

Papers overview

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Highly Cited
2015
Highly Cited
2015
Neutrophil IL-1β Processing Induced by Pneumolysin Is Mediated by the NLRP3/ASC Inflammasome and Caspase-1 Activation and Is Dependent on K+ Efflux
Although neutrophils are the most abundant cells in acute infection and inflammation, relatively little attention has been paid… 
Highly Cited
2011
Highly Cited
2011
The NLRP3 Inflammasome Contributes to Brain Injury in Pneumococcal Meningitis and Is Activated through ATP-Dependent Lysosomal Cathepsin B Release
Streptococcus pneumoniae meningitis causes brain damage through inflammation-related pathways whose identity and mechanisms of… 
Highly Cited
2011
Highly Cited
2011
Nod2 sensing of lysozyme-digested peptidoglycan promotes macrophage recruitment and clearance of S. pneumoniae colonization in mice.
Streptococcus pneumoniae colonizes the mucosal surface of the human upper respiratory tract. A colonization event is gradually… 
Highly Cited
2005
Highly Cited
2005
Antibody responses to nasopharyngeal carriage of Streptococcus pneumoniae in adults: a longitudinal household study.
BACKGROUND Natural immunity to Streptococcus pneumoniae is thought to be induced by exposure to S. pneumoniae or cross-reactive… 
Highly Cited
2003
Highly Cited
2003
Immunizations with pneumococcal surface protein A and pneumolysin are protective against pneumonia in a murine model of pulmonary infection with Streptococcus pneumoniae.
Intranasal infection of mice with certain strains of capsular group 19 Streptococcus pneumoniae can result in focal pneumonia in… 
Highly Cited
2000
Highly Cited
2000
Intranasal Immunization of Mice with a Mixture of the Pneumococcal Proteins PsaA and PspA Is Highly Protective against Nasopharyngeal Carriage of Streptococcus pneumoniae
ABSTRACT Acquisition of pneumococci is generally from carriers rather than from infected individuals. Therefore, to induce herd… 
Highly Cited
1994
Highly Cited
1994
Immunization of mice with pneumolysin toxoid confers a significant degree of protection against at least nine serotypes of Streptococcus pneumoniae
Pneumolysin is the thiol-activated cytolysin produced by Streptococcus pneumoniae. Mice were immunized with a genetically… 
Highly Cited
1994
Highly Cited
1994
Pneumolysin stimulates production of tumor necrosis factor alpha and interleukin-1 beta by human mononuclear phagocytes
Human peripheral blood monocytes and a human monocyte cell line were exposed to the toxin pneumolysin. Pneumolysin-exposed cells… 
Highly Cited
1989
Highly Cited
1989
Reduced virulence of a defined pneumolysin-negative mutant of Streptococcus pneumoniae
Insertion-duplication mutagenesis was used to construct a pneumolysin-negative derivative of Streptococcus pneumoniae. This was… 
Highly Cited
1987
Highly Cited
1987
Molecular cloning, characterization, and complete nucleotide sequence of the gene for pneumolysin, the sulfhydryl-activated toxin of Streptococcus pneumoniae
A recombinant lambda bacteriophage has been isolated that carries DNA from Streptococcus pneumoniae and expresses a potent… 
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