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Activation of neutrophils by autocrine IL-17A–IL-17RC interactions during fungal infection is regulated by IL-6, IL-23, RORγt and dectin-2
TLDR
A population of human and mouse neutrophils with autocrine IL-17 activity that probably contribute to the etiology of microbial and inflammatory diseases is identified. Expand
Targeted Disruption of the Chemokine Eotaxin Partially Reduces Antigen-induced Tissue Eosinophilia
TLDR
A contributory role for eotaxin is indicated in the generation of peripheral blood and antigen-induced tissue eosinophilia in the peripheral circulation, suggesting an important role in vivo of this C–C chemokine. Expand
Pathogenic Trichomonas vaginalis cytotoxicity to cell culture monolayers.
TLDR
Release of tritiated thymidine (3H-thymidine) of the deoxyribonucleic acid (DNA) of prelabelled host cells after incubation with T vaginalis corroborated that extensive cytotoxicity was caused by pathogenic trichomonads in man. Expand
Cutting Edge: Membrane Nanotubes In Vivo: A Feature of MHC Class II+ Cells in the Mouse Cornea1
TLDR
Identification of these novel cellular processes in the mammalian cornea provides the first evidence of membrane nanotubes in vivo in cell-cell communication between widely spaced dendritic cells during inflammation. Expand
Fusarium and Candida albicans Biofilms on Soft Contact Lenses: Model Development, Influence of Lens Type, and Susceptibility to Lens Care Solutions
TLDR
Using the developed in vitro biofilm model, it was shown that phylogenetically diverse planktonic fusaria and Candida were susceptible to MoistureLoc and MultiPlus, however, Fusarium biofilms exhibited reduced susceptibility against these solutions in a species- and time-dependent manner. Expand
Innate Immune Responses to Endosymbiotic Wolbachia Bacteria in Brugia malayi and Onchocerca volvulus Are Dependent on TLR2, TLR6, MyD88, and Mal, but Not TLR4, TRIF, or TRAM1
TLDR
It is established that the innate inflammatory pathways activated by endosymbiotic Wolbachia in B. malayi and O. volvulus filaria are dependent on TLR2-TLR6 interactions and are mediated by adaptor molecules MyD88 and TIRAP/Mal. Expand
Neutrophil IL-1β Processing Induced by Pneumolysin Is Mediated by the NLRP3/ASC Inflammasome and Caspase-1 Activation and Is Dependent on K+ Efflux
TLDR
An essential role for neutrophil-derived IL-1β in S. pneumoniae infection is demonstrated and the role of the NLRP3 inflammasome in cleavage and secretion of IL- 1β in neutrophils is elucidated, which will have implications for other microbial diseases. Expand
An essential role for interleukin-5 and eosinophils in helminth-induced airway hyperresponsiveness.
TLDR
Data indicate that IL-5 and eosinophils are required for the induction of AHR by filarial helminths, and that mice immunized with killed B. malayi in IL- 5(-/-) mice failed to show AHR in response to cholinergic agonists. Expand
Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1β secretion in response to ATP
TLDR
It is demonstrated that human and murine neutrophils express functional cell-surface P2X7R, which leads to ATP-induced loss of intracellular K+, NLRP3 inflammasome activation and IL-1β secretion by neutrophil, which likely has a significant, wide ranging clinical impact. Expand
Eotaxin is required for the baseline level of tissue eosinophils.
TLDR
It is demonstrated that eotaxin is a fundamental regulator of the physiological trafficking of eosinophils during healthy states and involvement in the baseline trafficking of leukocytes into nonhematopoietic tissue should now be considered. Expand
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