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Serotype-specific effectiveness and correlates of protection for the 13-valent pneumococcal conjugate vaccine: a postlicensure indirect cohort study.
The vaccine effectiveness for PCV13 and PCV7 was lower than predicted by the aggregate correlate of protection of 0·35 μg/mL used during licensing, and serotype-specific correlates of protection vary widely. Expand
The fundamental link between pneumococcal carriage and disease
The use of vaccine effect on carriage as part of the vaccine licensure and post-vaccine introduction evaluation could facilitate and expand the licensure of new, life-saving pneumococcal vaccines and enable a comprehensive estimate of population effects after vaccine introduction. Expand
Enzyme-Linked Immunosorbent Assay for Quantitation of Human Antibodies to Pneumococcal Polysaccharides
Streptococcus pneumoniae is a major human pathogen causing pneumonia, sepsis, meningitis, and otitis media, and elderly adults because their immune systems are either unprepared or unable to respond effectively to it. Expand
Dense genomic sampling identifies highways of pneumococcal recombination
Evasion of clinical interventions by Streptococcus pneumoniae occurs through selection of non-susceptible genomic variants. We report whole-genome sequencing of 3,085 pneumococcal carriage isolatesExpand
Serological criteria for evaluation and licensure of new pneumococcal conjugate vaccine formulations for use in infants.
This report analyses the various options with their relative merits and drawbacks and provides preliminary recommendations as guidance to regulatory agencies in evaluating these vaccines for the purposes of licensure. Expand
Effect of age, polymicrobial disease, and maternal HIV status on treatment response and cause of severe pneumonia in South African children: a prospective descriptive study
For children younger than 1 year, the WHO guidelines are inadequate and need to be revised since both HIV-infected and HIV-exposed, uninfected infants had more treatment failures than did HIV-uninfected infants. Expand
Serological Basis for Use of Meningococcal Serogroup C Conjugate Vaccines in the United Kingdom: Reevaluation of Correlates of Protection
The results indicated that the majority of toddlers with an rSBA titer between 8 and 64, and some of those with an hSBA result of <4, have mounted a protective immune response with the induction of immunological memory. Expand
Pathologic Antibodies to Platelet Factor 4 after ChAdOx1 nCoV-19 Vaccination
It is recommended that treatment with platelet transfusions be avoided because of the risk of progression in thrombotic symptoms and that the administration of a nonheparin anticoagulant agent and intravenous immune globulin be considered for the first occurrence of these symptoms. Expand
Combined schedules of pneumococcal conjugate and polysaccharide vaccines: is hyporesponsiveness an issue?
The evidence for and against this hyporesponsiveness can develop to repeated polysaccharide vaccine antigen exposures are described and the possible mechanisms for such an occurrence are explored. Expand
Antibody responses to nasopharyngeal carriage of Streptococcus pneumoniae in adults: a longitudinal household study.
Levels of anticapsular IgG increased significantly after carriage of serotypes 9V, 14, 18C, 19F, and 23F by an individual or family member, suggesting adults respond to NP carriage by mounting anticapular and weak antiprotein antibody responses, and naturally induced anticapsULAR IgG can prevent carriage. Expand