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pifithrin

 
National Institutes of Health

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Highly Cited
2009
Highly Cited
2009
Pifithrin-α (PFT-α) was shown to specifically block transcriptional activity of the tumor suppressor p53 and was therefore… Expand
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Highly Cited
2008
Highly Cited
2008
Autophagy is a cellular process of bulk degradation of damaged organelles, protein aggregates and other macromolecules in the… Expand
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Highly Cited
2005
Highly Cited
2005
The chemoprotection of cells from apoptosis induced by toxins or ionizing radiation could be important for biodefense and in the… Expand
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Highly Cited
2004
Highly Cited
2004
The present experiments were designed to evaluate the effects of pifithrin-α (PFT-α), which is a p53 inhibitor, on doxorubicin… Expand
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Highly Cited
2004
Highly Cited
2004
Doxorubicin (DOX), a widely used chemotherapeutic agent, exhibits cardiotoxicity as an adverse side effect in cancer patients… Expand
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Highly Cited
2004
Highly Cited
2004
No neuroprotective compounds are clinically available for the treatment of ischemic stroke. The potential salutary effect of… Expand
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Highly Cited
2004
Highly Cited
2004
Pifithrin-α (PFTα) was originally thought to be a specific inhibitor of signaling by the tumor suppressor protein p53. However… Expand
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Highly Cited
2003
Highly Cited
2003
We established previously that X-linked inhibitor of apoptosis protein (Xiap) is a determinant of cisplatin (CDDP) resistance in… Expand
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Highly Cited
2001
Highly Cited
2001
The tumor suppressor protein p53 is essential for neuronal death in several experimental settings and may participate in human… Expand
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Highly Cited
1999
Highly Cited
1999
Chemotherapy and radiation therapy for cancer often have severe side effects that limit their efficacy. Because these effects are… Expand
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