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pifithrin

National Institutes of Health

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4 relations

Broader (2)

BenzothiazolesToluene
analogs & derivativespifithrin-alpha

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
Lipopolysaccharide prevents valproic acid-induced apoptosis via activation of nuclear factor-κB and inhibition of p53 activation.
2011
2011
Mechanism of autophagy induction and role of autophagy in antagonizing mitomycin C-induced cell apoptosis in silibinin treated human melanoma A375-S2 cells.
2010
2010
5-Aza-2'-deoxycytidine sensitizes busulfan-resistant myeloid leukemia cells by regulating expression of genes involved in cell cycle checkpoint and apoptosis.
2009
2009
Diesel exhaust particles induce apoptosis via p53 and Mdm2 in J774A.1 macrophage cell line.
2006
2006
Multiple actions of pifithrin-alpha on doxorubicin-induced apoptosis in rat myoblastic H9c2 cells.
Doxorubicin (Dox) is a chemotherapeutic agent that causes significant cardiotoxicity. We showed previously that Dox activates p53… 
Highly Cited
2005
Highly Cited
2005
Loss of tumor suppressor p53 decreases PTEN expression and enhances signaling pathways leading to activation of activator protein 1 and nuclear factor kappaB induced by UV radiation.
Transcription factor p53 and phosphatase PTEN are two tumor suppressors that play essential roles in suppression of… 
Highly Cited
2004
Highly Cited
2004
Improvement of rat liver graft quality by pifithrin‐α–mediated inhibition of hepatocyte necrapoptosis
Early graft dysfunction due to ischemia reperfusion injury remains a major clinical challenge in liver transplantation. Because… 
2004
2004
Influence of altered apoptosis in human lymphoblastoid cell lines on micronucleus frequency.
Highly Cited
2002
Highly Cited
2002
Transformed and tumor-derived human cells exhibit preferential sensitivity to the thiol antioxidants, N-acetyl cysteine and penicillamine.
Thiol antioxidants, typified by N-acetyl cysteine, are known to induce p53-dependent apoptosis in transformed mouse embryo… 
Highly Cited
2001
Highly Cited
2001
Regulation of functional nuclear pore size in fibroblasts.
Protein-NLS-coated gold particles up to approximately 250 A in diameter are transported through the nuclear pores in normal… 
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