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pifithrin

National Institutes of Health

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4 relations

Broader (2)

BenzothiazolesToluene
analogs & derivativespifithrin-alpha

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
Lipopolysaccharide prevents valproic acid-induced apoptosis via activation of nuclear factor-κB and inhibition of p53 activation.
2011
2011
Mechanism of autophagy induction and role of autophagy in antagonizing mitomycin C-induced cell apoptosis in silibinin treated human melanoma A375-S2 cells.
2009
2009
Diesel exhaust particles induce apoptosis via p53 and Mdm2 in J774A.1 macrophage cell line.
2008
2008
Low doses of paclitaxel potently induce apoptosis in human retinoblastoma Y79 cells by up-regulating E2F1.
Paclitaxel (PTX) is an anticancer drug currently in phase II clinical trials. This study shows for the first time that low doses… 
2007
2007
Zebrafish tp53 knockdown extends the survival of irradiated zebrafish embryos more effectively than the p53 inhibitor pifithrin
Cancer treatment strategies using radiation therapy have significantly improved outcomes in patients. Although advances in… 
2006
2006
Multiple actions of pifithrin-alpha on doxorubicin-induced apoptosis in rat myoblastic H9c2 cells.
Doxorubicin (Dox) is a chemotherapeutic agent that causes significant cardiotoxicity. We showed previously that Dox activates p53… 
Highly Cited
2004
Highly Cited
2004
Improvement of rat liver graft quality by pifithrin‐α–mediated inhibition of hepatocyte necrapoptosis
Early graft dysfunction due to ischemia reperfusion injury remains a major clinical challenge in liver transplantation. Because… 
2004
2004
Influence of altered apoptosis in human lymphoblastoid cell lines on micronucleus frequency.
Highly Cited
2002
Highly Cited
2002
Transformed and tumor-derived human cells exhibit preferential sensitivity to the thiol antioxidants, N-acetyl cysteine and penicillamine.
Thiol antioxidants, typified by N-acetyl cysteine, are known to induce p53-dependent apoptosis in transformed mouse embryo… 
Highly Cited
2001
Highly Cited
2001
Regulation of functional nuclear pore size in fibroblasts.
Protein-NLS-coated gold particles up to approximately 250 A in diameter are transported through the nuclear pores in normal… 
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