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Big Mitogen-activated Kinase Regulates Multiple Members of the MEF2 Protein Family*
TLDR
It is demonstrated that, upon growth factor induction, BMK1 directly phosphorylates and activates three members of theMEF2 family of transcription factors thereby inducing MEF2-dependent gene expression. Expand
Protective Effects of a Human 18-Kilodalton Cationic Antimicrobial Protein (CAP18)-Derived Peptide against Murine Endotoxemia
TLDR
Results indicate that CAP18109–135 is capable of preventing antibiotic-induced endotoxic shock in mice with septicemia and that the effect is due to its LPS-neutralizing activity rather than to its antibacterial activity. Expand
Bacterial lipopolysaccharide induces osteoclast formation in RAW 264.7 macrophage cells.
TLDR
LPS-induced osteoclast formation was abolished by anti-tumor necrosis factor (TNF)-alpha antibody, but not antibodies to macrophage-colony stimulating factor (M-CSF) and receptor activator of nuclear factor (NF)-kappaB ligand (RANKL). Expand
Astrocyte elevated gene‐1 (AEG‐1) is induced by lipopolysaccharide as toll‐like receptor 4 (TLR4) ligand and regulates TLR4 signalling
TLDR
Astrocyte elevated gene‐1 was suggested to be a L PS‐responsive gene and involved in LPS‐induced inflammatory response and the prevention of AEG‐1 expression inhibited LPS •induced tumour necrosis factor‐α and prostaglandin E2 production. Expand
Olfactory transmission of neurotropic viruses
TLDR
The authors review the olfactory transmission of infectious agents and the resulting hazards to human and animal health. Expand
CpG‐DNA‐induced IFN‐α production involves p38 MAPK‐dependent STAT1 phosphorylation in human plasmacytoid dendritic cell precursors
TLDR
The results suggest that CpG DNA induces p38 MAPK‐dependent phosphorylation of STAT1 in a manner independent of IFN‐α/β, which may cause ISGF3 formation to increase the transcription of the IRF‐7 gene, thereby leading to IFn‐α production in human PDC. Expand
B lymphoblast antigen (BB-1) expressed on Epstein-Barr virus-activated B cell blasts, B lymphoblastoid cell lines, and Burkitt's lymphomas.
TLDR
Two new cell surface antigens expressed on B lymphoblastoid cell lines (B-LCL) were defined with cytotoxic mouse monoclonal antibodies and the finding that BB-1 was expressed on the Jijoye lymphoma but only marginally on a subline of JiJoye that lacks receptors for EBV and produces a defective virus incapable of transforming lymphocytes was of particular interest. Expand
Apoptotic cell death in the response of D-galactosamine-sensitized mice to lipopolysaccharide as an experimental endotoxic shock model
TLDR
It was suggested that lipopolysaccharide- induced hepatic injury and failure in D-galactosamine-sensitized mice was due to the apoptotic cell death of hepatocytes caused by tumor necrosis factor alpha released in the circulation. Expand
Human erythroleukemia cell line (HEL) undergoes a drastic macrophage-like shift with TPA.
TLDR
Comparative observations with K562 cells indicate that TPA inhibits, as in HEL cells, spontaneous and induced globin synthesis, but induces minimal macrophage-like properties in these cells. Expand
The vomeronasal chemosensory system as a route of neuroinvasion by herpes simplex virus.
TLDR
The results suggest that neurotropic viruses can invade the brain by infecting vomeronasal chemosensory neurons and that the restrained induction of apoptosis in the infected neurons may facilitate viral transmission to the CNS. Expand
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