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Inhibition of Glucocorticoid-induced Apoptosis by Targeting the Major Splice Variants of BIM mRNA with Small Interfering RNA and Short Hairpin RNA*
TLDR
Evidence is offered that the induction of Bim by GC is a required event for the complete apoptotic response in pre-B ALL cells, and that the extent of GC resistance correlated with siRNA silencing potency.
Molecular Determinants of Epidermal Growth Factor Binding: A Molecular Dynamics Study
TLDR
Results reveal that while several residues are conserved among the EGFR ligand family, no single set of residues determines the affinity class, and heterogeneous sets of interactions that were driven primarily by electrostatic and Van der Waals forces are found.
Coordinate control of cell cycle regulatory genes in zebrafish development tested by cyclin D1 knockdown with morpholino phosphorodiamidates and hydroxyprolyl-phosphono peptide nucleic acids
TLDR
Results indicate that transcription of key molecular determinants of asynchronous cell cycle control in zebrafish embryos commences at MBT and that the reduction of cyclin D1 expression compromises zebra fish eye and head development.
A c-myc antisense oligodeoxynucleotide inhibits entry into S phase but not progress from G0 to G1
TLDR
Exogenous addition to bulk cell cultures of small antisense oligomers inhibits mitogen-induced c-myc protein expression in human T lymphocytes and prevents S phase entry and Interestingly, c- myc antisense treatment did not inhibit G0 to G1 traversal as assessed by morphologic blast transformation, transcriptional activation of the IL-2R and TfR genes, or induction of 3H-uridine incorporation.
Human promyelocytic leukemia HL-60 cell proliferation and c-myc protein expression are inhibited by an antisense pentadecadeoxynucleotide targeted against c-myc mRNA.
TLDR
It appears that antisense oligodeoxynucleotides added to myc-transformed cells via culture medium are capable of eliciting sequence-specific, dose-dependent inhibition of c-myc protein expression and cell proliferation.
Integrated molecular targeting of IGF1R and HER2 surface receptors and destruction of breast cancer cells using single wall carbon nanotubes
TLDR
Quantitative analysis demonstrated that all the cells treated with SWCNT/IGF1R and HER2 specific antibody complex were completely destroyed, while more than 80% of the cells with SWcNT/non-specific antibody hybrids remained alive.
Targeting Apoptosis for Optical Imaging of Infection
TLDR
Targeting PS presented on the outer leaflet of apoptotic or necrotic neutrophils as well as gram-positive microorganism with PS-specific NIR fluorophore provides a sensitive means of imaging infection.
Interactions of antisense DNA oligonucleotide analogs with phospholipid membranes (liposomes).
TLDR
It is shown that MP-oligos exhibit saturable binding (adsorption) to liposomal membranes with a dissociation constant (Kd) of around 20nM, which suggests that cellular uptake of oligonucleotides by passive diffusion may be an unlikely mechanism, even for the more hydrophobic MP-OLigos, as biological effects are observed over much shorter time periods.
Single-wall carbon nanotube nanobomb agents for killing breast cancer cells
We report the first application of single-wall carbon nanotubes (SWCNT) as potent therapeutic nanobomb agents for killing breast cancer cells. We show here that by adsorbing water molecules in SWCNT
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