• Publications
  • Influence
A controlled trial of inpatient and outpatient geriatric evaluation and management.
BACKGROUND Over the past 20 years, both inpatient units and outpatient clinics have developed programs for geriatric evaluation and management. However, the effects of these interventions on survivalExpand
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Official positions of the International Society for Clinical Densitometry.
The International Society for Clinical Densitometry (ISCD) periodically holds Position Development Conferences for the purpose of establishing standards and guidelines for indications, acquisition,Expand
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Official positions of the International Society for Clinical Densitometry.
The International Society for Clinical Densitometry (ISCD) has convened two Position Development Conferences at which a panel of experts agreed on recommendations for performance and clinicalExpand
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Overexpression of Bcl-2 attenuates apoptosis and protects against myocardial I/R injury in transgenic mice.
To test whether the antiapoptotic protein Bcl-2 prevents apoptosis and injury of cardiomyocytes after ischemia-reperfusion (I/R), we generated a line of transgenic mice that carried a human Bcl-2Expand
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Necrostatin‐1 protects against glutamate‐induced glutathione depletion and caspase‐independent cell death in HT‐22 cells
Glutamate, a major excitatory neurotransmitter in the CNS, plays a critical role in neurological disorders such as stroke and Parkinson’s disease. Recent studies have suggested that glutamate excessExpand
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Overexpression of MnSOD protects against myocardial ischemia/reperfusion injury in transgenic mice.
  • Z. Chen, B. Siu, +4 authors B. Chua
  • Medicine
  • Journal of molecular and cellular cardiology
  • 1 November 1998
Generation of free radicals upon reperfusion has been cited as one of the major causes of ischaemia/reperfusion injury. The following series of experiments was designed to study the effect ofExpand
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Upregulation of vascular endothelial growth factor by H2O2 in rat heart endothelial cells.
Hydrogen peroxide (H2O2) is a reactive oxygen species generated by several metabolic pathways in mammalian cells. Endothelial cells are extremely susceptible to oxidative stress. H2O2 has beenExpand
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Humanin Is a Novel Neuroprotective Agent Against Stroke
Background and Purpose— Humanin (HN) is a 24-amino acid peptide best known for its ability to protect neurons from damage caused by Alzheimer disease-related proteins. This study examines theExpand
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Upregulation of vascular endothelial growth factor by angiotensin II in rat heart endothelial cells.
Vascular endothelial growth factor (VEGF) is a potent mitogen for endothelial cells and a vascular permeability factor. In this study we found that the addition of angiotensin II (AII) to rat heartExpand
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Which central dual X-ray absorptiometry skeletal sites and regions of interest should be used to determine the diagnosis of osteoporosis?
Although central measurement of bone mass by dual X-ray absorptiometry (DXA) is viewed by many as the "gold standard" for the diagnosis of osteoporosis in patients without previous fragilityExpand
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