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phosphocitrate

Known as: 1,2,3-propanetricarboxylic acid, 2-(phosphonooxy)- 
National Institutes of Health

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2 relations

Broader (2)

Citratesphosphocitric acid

Papers overview

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2007
2007
A novel strategy for the preparation of naturally occurring phosphocitrate and its partially esterified derivatives.
A novel method for the synthesis of phosphocitrate (1, PC) starting from triethyl ester of citric acid and MeOPCl2 is described… 
Highly Cited
2004
Highly Cited
2004
Basic calcium phosphate crystal-induced prostaglandin E2 production in human fibroblasts: role of cyclooxygenase 1, cyclooxygenase 2, and interleukin-1beta.
OBJECTIVE To elucidate the mechanism of basic calcium phosphate (BCP) crystal-induced prostaglandin E(2) (PGE(2)) production in… 
2003
2003
Phosphocitrate Inhibits Calcium Hydroxyapatite Induced Mitogenesis and Upregulation of Matrix Metalloproteinase-1, Interleukin-1β and Cyclooxygenase-2 mRNA in Human Breast Cancer Cell Lines
Microcalcifications containing calcium hydroxyapatite (HA) are often associated with malignant human breast lesions. Frequently… 
2001
2001
A crystallographically characterized nine-coordinate calcium-phosphocitrate complex as calcification inhibitor in vivo.
Calcium-containing crystal deposition diseases represent a group of clinically heterogeneous calcific diseases that are a… 
1999
1999
Phosphocitrate blocks nitric oxide-induced calcification of cartilage and chondrocyte-derived apoptotic bodies.
OBJECTIVE To examine whether phosphocitrate (PC) will block nitric oxide-induced calcification of cartilage or chondrocyte… 
Highly Cited
1999
Highly Cited
1999
Basic calcium phosphate crystal induction of collagenase 1 and stromelysin expression is dependent on a p42/44 mitogen‐activated protein kinase signal transduction pathway
Synovial fluid basic calcium phosphate (BCP) crystals are markers of severe joint degeneration in osteoarthritis. These crystals… 
1996
1996
Inhibition of Calcium Pyrophosphate Dihydrate Crystal Formation in Articular Cartilage Vesicles and Cartilage by Phosphocitrate*
Articular cartilage vesicles (ACV), isolated by differential centrifugation of adult hyaline articular cartilage collagenase… 
1995
1995
Controlling influence of phosphocitrate in vitro and in vivo on calcium oxalate crystal formation and growth.
Calcium oxalate (CaOx) crystallization in the presence of phosphocitrate (PC) was studied by both in vitro and in vivo techniques… 
Highly Cited
1993
Highly Cited
1993
Phosphocitrate prevents disease progression in murine progressive ankylosis.
OBJECTIVE Mice with progressive ankylosis, a spontaneous arthropathy, were treated with phosphocitrate (PC) in vivo to determine… 
1981
1981
Phosphocitrate inhibits mitochondrial and cytosolic accumulation of calcium in kidney cells in vivo.
Synthetic 3-phosphocitrate, an extremely potent inhibitor of calcium phosphate crystallization as determined in a nonbiological… 
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