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Integrated analysis of isopentenyl pyrophosphate (IPP) toxicity in isoprenoid-producing Escherichia coli.
Isopentenyl pyrophosphate (IPP) toxicity presents a challenge in engineered microbial systems since its formation is unavoidable in terpene biosynthesis. In this work, we develop an experimentalExpand
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Systematic Study of the Physicochemical Properties of a Homologous Series of Aminobisphosphonates
Aminobisphosphonates, e.g., alendronate and neridronate, are a well known class of molecules used as drugs for various bone diseases. Although these molecules have been available for decades, aExpand
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A bisphosphonate increasing the shoot biomass of the metal hyperaccumulator Noccaea caerulescens.
The feasibility of using the hyperaccumulator plant, Noccaea caerulescens, to remove trace elements from contaminated soils has been studied extensively. However, this plant creates too low biomassExpand
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Bisphosphonate prodrugs: synthesis and in vitro evaluation of alkyl and acyloxymethyl esters of etidronic acid as bioreversible prodrugs of etidronate.
The synthesis and preliminary evaluation of novel alkyl and acyloxymethyl esters of etidronic acid as etidronate prodrugs is reported. Tetramethyl ester of etidronic acid was found be isomerized atExpand
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Structural requirements for bisphosphonate binding on hydroxyapatite: NMR study of bisphosphonate partial esters.
Eighteen different bisphosphonates, including four clinically used bisphosphonate acids and their phosphoesters, were studied to evaluate how the bisphosphonate structure affects binding to bone.Expand
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Advanced material and approach for metal ions removal from aqueous solutions
A Novel approach to remove metals from aqueous solutions has been developed. The method is based on a resin free, solid, non-toxic, microcrystalline bisphosphonate material, which has very lowExpand
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Bisphosphonate-Generated ATP-Analogs Inhibit Cell Signaling Pathways.
Bisphosphonates are a major class of drugs used to treat osteoporosis, Paget's disease, and cancer. They have been proposed to act by inhibiting one or more targets including protein prenylation, theExpand
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Selective Calcium-Dependent Inhibition of ATP-Gated P2X3 Receptors by Bisphosphonate-Induced Endogenous ATP Analog ApppI
Pain is the most unbearable symptom accompanying primary bone cancers and bone metastases. Bone resorptive disorders are often associated with hypercalcemia, contributing to the pathologic process.Expand
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A novel bisphosphonate-based solid phase method for effective removal of chromium(III) from aqueous solutions and tannery effluents
Effective removal of chromium(III) from waste waters e.g. in the leather industry is required due to continuously tightening environmental regulations, and several methods such as precipitation andExpand
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Bisphosphonate Prodrugs. Selective Synthesis of (1-Hydroxyethylidene)-1,1-bisphosphonate Partial Esters
Selective methods for the synthesis of (1-hydroxyeth- ylidene)-1,1-bisphosphonate tri-, P,P -di-, P,P-di- and mono esters have been developed. Preparation is started from selected symmet- ric orExpand
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