Spectrophotometric assay and properties of the angiotensin-converting enzyme of rabbit lung.
Design of potent competitive inhibitors of angiotensin-converting enzyme. Carboxyalkanoyl and mercaptoalkanoyl amino acids.
Effects of Cyclic Compressive Loading on Chondrogenesis of Rabbit Bone‐Marrow Derived Mesenchymal Stem Cells
- C. Huang, Kristen L. Hagar, Lauren E. Frost, Yubo Sun, H. Cheung
- Biology, MedicineStem Cells
- 1 May 2004
It is suggested that cyclic compressive loading can promote the chondrogenesis of rabbit BM‐MSCs by inducing the synthesis of TGF‐β1, which can stimulate the BM‐ MSCs to differentiate into chondrocytes.
Binding of peptide substrates and inhibitors of angiotensin-converting enzyme. Importance of the COOH-terminal dipeptide sequence.
- H. Cheung, F. Wang, M. Ondetti, E. F. Sabo, D. W. Cushman
- Biology, ChemistryJournal of Biological Chemistry
- 25 January 1980
Results suggest that selective binding of the COOH-terminal dipeptide residue is an impor tan t dete rminant of both the substrate specificity of angiotensin-converting enzyme and the degree of rate stimulation by chloride ion, and that the nature of this selective binding can be further clarified by studying competitive inhibition of dpeptides of vary ing structure.
Concentrations of angiotensin-converting enzyme in tissues of the rat.
Dual metalloprotease inhibitors: mercaptoacetyl-based fused heterocyclic dipeptide mimetics as inhibitors of angiotensin-converting enzyme and neutral endopeptidase.
A series of 7,6- and 7,5-fused bicyclic thiazepinones and oxazepinones were generated and incorporated as conformationally restricted dipeptide surrogates in mercaptoacyl dipePTides, and compound 1a (BMS-186716) was advanced into clinical development for the treatment of hypertension and congestive heart failure.
New insight into deformation-dependent hydraulic permeability of gels and cartilage, and dynamic behavior of agarose gels in confined compression.
Cyclic compression maintains viability and induces chondrogenesis of human mesenchymal stem cells in fibrin gel scaffolds.
Results show that cyclic compression (10% strain) at frequencies >0.5 Hz and gel concentration of 40 mg/mL fibrinogen appears to maintain cellular viability within scaffolds, and variations in gel component concentration and stimulus frequency can be modified such that a significant chondrogenic response can be achieved by hMSC in fibrIn constructs after 8 h of compression spread out over 2 days.
Regulation of matrix metalloproteinase (MMP) gene expression by protein kinases.
This review focuses on the regulation of the MMPs by the protein kinases at the level of gene expression and their signaling pathways.
Balance between polyoma enhancing activator 3 and activator protein 1 regulates Helicobacter pylori-stimulated matrix metalloproteinase 1 expression.
Cag PAI and OipA provide a possible link between bacterial virulence factors and important host factors related to disease pathogenesis and MMP-1 and pea-3 activities are increased in gastric cancers.