• Publications
  • Influence
Determination of glutathione and glutathione disulfide in biological samples.
  • M. Anderson
  • Chemistry, Medicine
  • Methods in enzymology
  • 1985
TLDR
5,5'-dithiobis(2-nitrobenzoic acid) (DTNB)-GSSG reductase recycling assay for total glutathione is a specific, sensitive, rapid, and reliable procedure, however, because the method depends on an accurate standard curve, appropriate standards containing the protein precipitating agent are essential. Expand
Glutathione: an overview of biosynthesis and modulation.
  • M. Anderson
  • Chemistry, Medicine
  • Chemico-biological interactions
  • 24 April 1998
TLDR
Treatment with an inhibitor, buthionine sulfoximine (BSO), of gamma-glutamylcysteine synthetase leads to decreased cellular GSH levels, and its application can provide a useful experimental model of GSH deficiency. Expand
CoREST: a functional corepressor required for regulation of neural-specific gene expression.
TLDR
It is shown that CoREST, a newly identified human protein, functions as a corepressor for REST, a structural feature of the nuclear receptor and silencing mediator for retinoid and thyroid human receptors (SMRT)-extended corepressors that mediate inducible repression by steroid hormone receptors. Expand
High resistance to cisplatin in human ovarian cancer cell lines is associated with marked increase of glutathione synthesis.
TLDR
The highly resistant cell lines obtained are proving useful for studying the multiple mechanisms by which tumor cells acquire drug- and radiation-resistance, and the potential value of examining regulation of glutathione synthesis as an indicator of clinical prognosis is suggested. Expand
KN-93, an inhibitor of multifunctional Ca++/calmodulin-dependent protein kinase, decreases early afterdepolarizations in rabbit heart.
TLDR
A novel association between CaM kinase activation and EADs is shown and this is consistent with the hypothesis that the ICa and CaM Kinase activation both contribute to Eads in this model. Expand
p53 domains: identification and characterization of two autonomous DNA-binding regions.
TLDR
This finding strongly argues that the DNA-binding activity of p53 segment 80-290 is physiologically significant and the role of tetramerization in p53 function remains to be determined. Expand
Glutathione and glutathione delivery compounds.
  • M. Anderson
  • Chemistry, Medicine
  • Advances in pharmacology
  • 1997
TLDR
The several methods for modulating cellular GSH levels presented in this chapter offer selective tools to study mechanisms and offer potential therapy of human diseases associated with GSH deficiency and oxidative stress. Expand
Determinants for Calmodulin Binding on Voltage-dependent Ca2+ Channels*
TLDR
The binding of the IQ and CB peptides to calmodulin appears to be competitive, signifying that the two sequences represent either independent or alternative binding sites for cal modulin rather than both sequences contributing to a single binding site. Expand
Catalytic and regulatory properties of the heavy subunit of rat kidney gamma-glutamylcysteine synthetase.
TLDR
The light subunit of gamma-glutamylcysteine synthetase has a regulatory function affecting the affinity of the enzyme for glutamate and GSH and feedback inhibition by GSH involves reduction of the enzymatic activity and also competition between G SH and glutamate for the glutamate site. Expand
Replacement by homologous recombination of the minK gene with lacZ reveals restriction of minK expression to the mouse cardiac conduction system.
TLDR
The restricted nature of minK expression in the mouse heart suggests species-specific roles of this gene product in mediating the electrophysiological properties of the heart. Expand
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