Skip to search formSkip to main contentSkip to account menu

phosphatidylinositol 3-kinase complex, class IB

Known as: 1-phosphatidylinositol-4-phosphate 3-kinase, class IB complex location, phosphatidylinositol 3-kinase complex location, class IB, 1-phosphatidylinositol-4-phosphate 3-kinase, class IB complex 
A class I phosphatidylinositol 3-kinase complex that possesses 1-phosphatidylinositol-4-phosphate 3-kinase activity; comprises a catalytic class IB… 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
Oncogenic mutations mimic and enhance dynamic events in the natural activation of phosphoinositide 3-kinase p110α (PIK3CA)
The p110α catalytic subunit (PIK3CA) is one of the most frequently mutated genes in cancer. We have examined the activation of… 
Highly Cited
2009
Highly Cited
2009
Ras is an indispensable coregulator of the class IB phosphoinositide 3-kinase p87/p110γ
Class IB phosphoinositide 3-kinase γ (PI3Kγ) elicits various immunologic and cardiovascular responses; however, the molecular… 
Highly Cited
2005
Highly Cited
2005
PI 3-kinase p110beta: a new target for antithrombotic therapy.
Platelet activation at sites of vascular injury is essential for the arrest of bleeding; however, excessive platelet accumulation… 
Highly Cited
2004
Highly Cited
2004
The MUC1 Oncoprotein Activates the Anti-apoptotic Phosphoinositide 3-Kinase/Akt and Bcl-xL Pathways in Rat 3Y1 Fibroblasts*
The MUC1 transmembrane glycoprotein is overexpressed by most human carcinomas. Overexpression of MUC1 confers transformation… 
Highly Cited
2002
Highly Cited
2002
Hyperinsulinemia, glucose intolerance, and dyslipidemia induced by acute inhibition of phosphoinositide 3-kinase signaling in the liver.
The physiological relevance of phosphoinositide 3-kinase (PI 3-K) signaling in the liver to fuel homeostasis was investigated… 
Highly Cited
2001
Highly Cited
2001
A Critical Role for Phosphoinositide 3-Kinase Upstream of Gab1 and SHP2 in the Activation of Ras and Mitogen-activated Protein Kinases by Epidermal Growth Factor*
Although the mechanisms involved in the activation of mitogen-activated protein kinases (MAPK) by receptor tyrosine kinases do… 
Highly Cited
2001
Highly Cited
2001
The Phosphoinositide-dependent Kinase, PDK-1, Phosphorylates Conventional Protein Kinase C Isozymes by a Mechanism That Is Independent of Phosphoinositide 3-Kinase*
Phosphorylation by the phosphoinositide-dependent kinase, PDK-1, is required for the activation of diverse members of the AGC… 
Highly Cited
1999
Highly Cited
1999
Integrin-linked kinase and PINCH: partners in regulation of cell-extracellular matrix interaction and signal transduction.
Integrin-linked kinase (ILK) is a focal adhesion serine/threonine protein kinase that is emerging as a key signaling protein… 
Highly Cited
1998
Highly Cited
1998
The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway.
The PTEN/MMAC1 phosphatase is a tumor suppressor gene implicated in a wide range of human cancers. Here we provide biochemical… 
Highly Cited
1998
Highly Cited
1998
Identification and characterization of a new oncogene derived from the regulatory subunit of phosphoinositide 3‐kinase
p85/p110 phosphoinositide 3‐kinase (PI3K) is a heterodimer composed of a p85‐regulatory and a p110‐catalytic subunit, which is… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)