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PIP4kγ is a substrate for mTORC1 that maintains basal mTORC1 signaling during starvation
A feedback loop involving PIP4kγ and mTORC1 maintains basal mTORC1 activity under nutrient-deprived conditions. Maintaining a Basal Level of Activity Nutrients such as glucose and amino acidsExpand
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Increased affinity and solubility of peptides used for direct peptide ELISA on polystyrene surfaces through fusion with a polystyrene-binding peptide tag.
Peptide reagents can serve as alternatives or replacements to antibodies in sensing or diagnostic applications. The passive adsorption of peptides onto polystyrene surfaces can limit the targetExpand
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Serum Withdrawal-Induced Accumulation of Phosphoinositide 3-Kinase Lipids in Differentiating 3T3-L6 Myoblasts: Distinct Roles for Ship2 and PTEN
ABSTRACT Phosphoinositide 3-kinase (PI3K) activation and synthesis of phosphatidylinositol-3,4-bisphosphate (PI-3,4-P2) and phosphatidylinositol-3,4,5-trisphosphate (PI-3,4,5-P3) lipids mediateExpand
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High-Throughput, Cell-Free, Liposome-Based Approach for Assessing In Vitro Activity of Lipid Kinases
Lipid kinases are central players in lipid signaling pathways involved in inflammation, tumorigenesis, and metabolic syndrome. A number of these kinase targets have proven difficult to investigate inExpand
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A General Synthetic Approach for Designing Epitope Targeted Macrocyclic Peptide Ligands.
We describe a general synthetic strategy for developing high-affinity peptide binders against specific epitopes of challenging protein biomarkers. The epitope of interest is synthesized as aExpand
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Bacterial Display Peptides for Use in Biosensing Applications
Peptide affinity reagent technology including bacterial display encapsulates an in vitro analog of classical Darwinian evolution through a physical linkage between polypeptide sequence and theExpand
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Genetically Engineered Peptides for Inorganics: Study of an Unconstrained Bacterial Display Technology and Bulk Aluminum Alloy
The first-ever peptide biomaterial discovery using an unconstrained engineered bacterial display technology is reported. Using this approach, we have developed genetically engineered peptide bindersExpand
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Peptide-based protein capture agents with high affinity, selectivity, and stability as antibody replacements in biodetection assays
Current biodetection assays that employ monoclonal antibodies as primary capture agents exhibit limited fieldability, shelf life, and performance due to batch-to-batch production variability andExpand
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Protein catalyzed capture agents with tailored performance for in vitro and in vivo applications
We report on peptide‐based ligands matured through the protein catalyzed capture (PCC) agent method to tailor molecular binders for in vitro sensing/diagnostics and in vivo pharmacokineticsExpand
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Cloning and Expressing Recombinant Protective Antigen Domains of B. anthracis
Abstract : Protective antigen (PA) of Bacillus anthracis is a four-domain protein that is required for transport of edema factor (EF) and lethal factor (LF) into host cells during anthrax infection.Expand
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