• Publications
  • Influence
Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling.
We report that knocking down the expression of inositol polyphosphate 4-phosphatase type II (INPP4B) in human epithelial cells, like knockdown of PTEN, resulted in enhanced Akt activation andExpand
  • 396
  • 45
The Role of Phosphoinositide 3-Kinase Lipid Products in Cell Function*
Phosphoinositide 3-kinases (PI 3-Ks) are a subfamily of lipid kinases that catalyze the addition of a phosphate molecule specifically to the 3-position of the inositol ring of phosphoinositides.Expand
  • 1,025
  • 44
AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer.
Dysregulation of the phosphatidylinositol 3-kinase (PI3K) signaling pathway occurs frequently in human cancer. PTEN tumor suppressor or PIK3CA oncogene mutations both direct PI3K-dependentExpand
  • 461
  • 36
Distinct roles of class I and class III phosphatidylinositol 3-kinases in phagosome formation and maturation
Phagosomes acquire their microbicidal properties by fusion with lysosomes. Products of phosphatidylinositol 3-kinase (PI 3-kinase) are required for phagosome formation, but their role in maturationExpand
  • 496
  • 32
  • PDF
SopB promotes phosphatidylinositol 3-phosphate formation on Salmonella vacuoles by recruiting Rab5 and Vps34
Salmonella colonizes a vacuolar niche in host cells during infection. Maturation of the Salmonella-containing vacuole (SCV) involves the formation of phosphatidylinositol 3-phosphate (PI(3)P) on itsExpand
  • 184
  • 25
  • PDF
Identification of the miR-106b~25 MicroRNA Cluster as a Proto-Oncogenic PTEN-Targeting Intron That Cooperates with Its Host Gene MCM7 in Transformation
A microRNA network regulates the tumor suppressor PTEN in prostate cancer. A Malignant Combination The abundance of microRNAs (miRNAs), tiny non–protein-coding RNAs that act as posttranscriptionalExpand
  • 391
  • 22
A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate
Phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2), a key molecule in the phosphoinositide signalling pathway, was thought to be synthesized exclusively by phosphorylation of PtdIns-4-P at the D-5Expand
  • 391
  • 19
A Comparative Analysis of the Phosphoinositide Binding Specificity of Pleckstrin Homology Domains*
Pleckstrin homology (PH) and phosphotyrosine binding (PTB) domains are structurally related regulatory modules that are present in a variety of proteins involved in signal transduction, such asExpand
  • 480
  • 18
  • PDF
Targeting Plasmodium PI(4)K to eliminate malaria
Achieving the goal of malaria elimination will depend on targeting Plasmodium pathways essential across all life stages. Here we identify a lipid kinase, phosphatidylinositol-4-OH kinase (PI(4)K), asExpand
  • 263
  • 17
A novel HPLC-based approach makes possible the spatial characterization of cellular PtdIns5P and other phosphoinositides.
PtdIns5P was discovered in 1997 [Rameh, Tolias, Duckworth and Cantley (1997) Nature 390, 192-196], but still very little is known about its regulation and function. Hitherto, studies of PtdIns5PExpand
  • 109
  • 14