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The Role of Phosphoinositide 3-Kinase Lipid Products in Cell Function*
TLDR
The most recent advances in the understanding of the role of PI 3-K in cell function are reviewed by dissecting the contribution of each of its lipid products.
Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling.
TLDR
It is reported that knocking down the expression of inositol polyphosphate 4-phosphatase type II in human epithelial cells, like knockdown of PTEN, resulted in enhanced Akt activation and anchorage-independent growth and enhanced overall motility, suggesting that INPP4B is a tumor suppressor.
AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer.
TLDR
It is shown through phosphoprotein profiling and functional genomic studies that many PIK3CA mutant cancer cell lines and human breast tumors exhibit only minimal AKT activation and a diminished reliance on AKT for anchorage-independent growth.
Distinct roles of class I and class III phosphatidylinositol 3-kinases in phagosome formation and maturation
TLDR
It is found that phosphatidylinositol 3-phosphate (PI[3]P) accumulates greatly but transiently on the phagosomal membrane, and the possibility that PI(3)P production by VPS34 may be targeted during the maturation arrest induced by some intracellular parasites is raised.
SopB promotes phosphatidylinositol 3-phosphate formation on Salmonella vacuoles by recruiting Rab5 and Vps34
TLDR
It is revealed that SopB mediates PI(3)P production on the SCV indirectly through recruitment of Rab5 and its effector Vps34 and a link between phosphoinositide phosphatase activity and the recruited Rab5 to phagosomes is revealed.
Identification of the miR-106b~25 MicroRNA Cluster as a Proto-Oncogenic PTEN-Targeting Intron That Cooperates with Its Host Gene MCM7 in Transformation
TLDR
A proto-oncogenic miRNA-dependent network for PTEN regulation is uncovered and the MCM7 locus is defined as a critical factor in initiating prostate tumorigenesis.
A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate
TLDR
Although PtdIns-5-P was previously thought not to exist in vivo, evidence is found for the presence of this lipid in mammalian fibroblasts, establishing a new pathway for PTDIns-4,5- P2 synthesis.
A Comparative Analysis of the Phosphoinositide Binding Specificity of Pleckstrin Homology Domains*
TLDR
It is shown that the Bruton’s tyrosine kinase PH domain binds to PtdIns-3,4,5-P3 with higher affinity than to PtsdIns-4, 5-P2, Ptdins- 3,4-4-P1 or inositol 1,3, 4-5-tetrakisphosphate (Ins-1, 3, 4,5 -P4).
Targeting Plasmodium PI(4)K to eliminate malaria
TLDR
It is shown that imidazopyrazines exert their effect through inhibitory interaction with the ATP-binding pocket of PI(4)K, altering the intracellular distribution of phosphatidylinositol-4-phosphate.
A novel HPLC-based approach makes possible the spatial characterization of cellular PtdIns5P and other phosphoinositides.
TLDR
A new HPLC method is described, which makes possible accurate measurements of basal and inducible levels of cellular PtdIns5P in the context of other phosphoinositides, and indicates that basal Ptdins5P and the Ptd Ins(4,5)P(2) synthesis may play a role in Golgi-mediated vesicle trafficking.
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