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petrosaspongiolide m

National Institutes of Health

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Broader (1)

Oleanolic Acid
analogs & derivatives

Papers overview

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2012
2012
Modulation of Proteasome Machinery by Natural and Synthetic Analogues of the Marine Bioactive Compound Petrosaspongiolide M
Natural or synthetic? Several petrosaspongiolide M natural and synthetic analogues have been tested as proteasome inhibitors and… 
2008
2008
Development of a second generation of inhibitors of microsomal prostaglandin E synthase 1 expression bearing the gamma-hydroxybutenolide scaffold.
Highly Cited
2007
Highly Cited
2007
Synthesis and pharmacological evaluation of a selected library of new potential anti-inflammatory agents bearing the gamma-hydroxybutenolide scaffold: a new class of inhibitors of prostanoid…
As a part of our drug discovery effort, recently we clarified the molecular basis of phospholipase A2 (PLA2) inactivation by… 
2005
2005
Inhibition Analysis of Human Group IIA Phospholipase A 2 by Petrosaspongiolide M Supports a Novel Mechanism of Protein-Protein Trans-Inactivation
The molecular mechanism for the inhibition of human group IIA secretory Phospholipase A2 (sPLA2-IIA) by the natural anti… 
2004
2004
PLA2‐mediated catalytic activation of its inhibitor 25‐acetyl‐petrosaspongiolide M: serendipitous identification of a new PLA2 suicide inhibitor
2003
2003
Inhibition of the NF-κB signaling pathway mediates the anti-inflammatory effects of petrosaspongiolide M
2003
2003
Petrosaspongiolide M reduces morphine withdrawal in vitro.
2002
2002
Molecular Basis of Phospholipase A2 Inhibition by Petrosaspongiolide M
Petrosaspongiolide M (PM) is an anti‐inflammatory marine metabolite that displays a potent inhibitory activity toward group II… 
Highly Cited
1999
Highly Cited
1999
Effects of petrosaspongiolide M, a novel phospholipase A2 inhibitor, on acute and chronic inflammation.
The marine product petrosaspongiolide M is a novel inhibitor of phospholipase A2 (PLA2), showing selectivity for secretory PLA2… 
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