Steroidal oligoglycosides and polyhydroxysteroids from echinoderms.
- L. Minale, R. Riccio, F. Zollo
- Biology, Environmental ScienceFortschritte der Chemie organischer Naturstoffe…
- 8 November 1994
Saponins, complex water soluble compounds composed of a carbohydrate moiety attached to a steroid or triterpenoid aglycone, have been isolated from a great number of terrestrial plants, but are uncommon animal constituents.
Tolaasins A--E, five new lipodepsipeptides produced by Pseudomonas tolaasii.
- C. Bassarello, S. Lazzaroni, A. Evidente
- Chemistry, BiologyJournal of Natural Products
- 17 April 2004
Among the target microorganisms used (fungi, yeast, and bacteria) the Gram-positive bacteria were the most sensitive, although the antimicrobial activity appeared to be correlated to the structural modification in the different analogues.
Determination of relative configuration in organic compounds by NMR spectroscopy and computational methods.
- G. Bifulco, P. Dambruoso, L. Gomez‐Paloma, R. Riccio
- ChemistryChemical Reviews
- 25 July 2007
Polycyclic guanidine alkaloids from the marine sponge Crambe crambe and Ca++ channel blocker activity of crambescidin 816.
- R. Berlinck, J. Braekman, E. Speroni
- Chemistry, BiologyJournal of Natural Products
- 1 July 1993
Four pentacyclic guanidine derivatives related to ptilomycalin A have been isolated from the Mediterranean sponge Crambe crambe and were found to have a potent Ca++ antagonist effect and to inhibit the acetylcholine-induced contraction of guinea pig ileum at very low concentrations.
Synthesis and pharmacological evaluation of a selected library of new potential anti-inflammatory agents bearing the gamma-hydroxybutenolide scaffold: a new class of inhibitors of prostanoid…
- M. D. Guerrero, M. Aquino, L. Gomez‐Paloma
- Biology, ChemistryJournal of Medicinal Chemistry
- 4 April 2007
A promising inhibitor of prostanoid production acting by in vitro and in vivo selective modulation of microsomal prostaglandin E synthase 1 expression is discovered.
New bisindole alkaloids of the topsentin and hamacanthin classes from the Mediterranean marine sponge Rhaphisia lacazei.
- A. Casapullo, G. Bifulco, I. Bruno, R. Riccio
- Chemistry, BiologyJournal of Natural Products
- 15 March 2000
The major compounds 1-3 were tested in vitro for antitumor activity; compounds 2 and 3 showed antiproliferative activity against human bronchopulmonary cancer cells (NSCLC-N6) with an IC(50) of 12 and 6.3 microg/mL, respectively.
Anti-inflammatory and analgesic activity of a novel inhibitor of microsomal prostaglandin E synthase-1 expression.
- M. D. Guerrero, M. Aquino, I. Bruno, R. Riccio, M. Terencio, M. Payá
- Biology, MedicineEuropean Journal of Pharmacology
- 12 October 2009
Chemical proteomics-driven discovery of oleocanthal as an Hsp90 inhibitor.
- L. Margarucci, M. Monti, A. Casapullo
- Biology, ChemistryChemical Communications
- 4 June 2013
Hsp90, a key target in cancer therapy, has been identified as the main partner of oleocanthal, an olive oil bioactive compound and its mechanism of action at the molecular level was disclosed.
Chemical and biological investigation of the polar constituents of the starfish Luidia clathrata, collected in the Gulf of Mexico.
- M. Iorizzi, P. Bryan, F. Zollo
- ChemistryJournal of Natural Products
- 1 May 1995
Ten new and three known polyhydroxysteroids were isolated from the starfish Luidia clathrata, collected from the offshore waters of the northern Gulf of Mexico, and they are all potent inhibitors of settlement.
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