Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines
The MISEV2018 guidelines include tables and outlines of suggested protocols and steps to follow to document specific EV-associated functional activities, and a checklist is provided with summaries of key points.
Transcription Factor NRF2 as a Therapeutic Target for Chronic Diseases: A Systems Medicine Approach
NRF2 represents one of the first targets fully embraced by classic and systems medicine approaches to facilitate both drug development and drug repurposing by focusing on a set of disease phenotypes that appear to be mechanistically linked.
Microvesicles from Human Adipose Tissue-Derived Mesenchymal Stem Cells as a New Protective Strategy in Osteoarthritic Chondrocytes
- M. Tofiño-Vian, M. I. Guillén, M. D. Pérez del Caz, A. Silvestre, M. Alcaraz
- Biology, MedicineCellular Physiology and Biochemistry
- 9 May 2018
The data support the interest of AD-MSC extracellular vesicles to develop new therapeutic approaches in joint conditions and show the reduction of inflammatory and catabolic mediators could be the consequence of a lower activation of nuclear factor-κB and activator protein-1.
Co-regulation between cyclo-oxygenase-2 and inducible nitric oxide synthase expression in the time-course of murine inflammation
The results indicate that PGE2 and NO may play in vivo mutual modulatory roles in the inflammatory response caused by zymosan injection into the mouse air pouch, a suitable model to study drugs acting on those pathways.
The carbon monoxide‐releasing molecule CORM‐2 inhibits the inflammatory response induced by cytokines in Caco‐2 cells
This study has investigated whether tricarbonyl dichloro ruthenium(II) dimer (CORM‐2) can control the inflammatory response induced by cytokines in a human colonic epithelial cell line, Caco‐2.
Extracellular Vesicles from Adipose-Derived Mesenchymal Stem Cells Downregulate Senescence Features in Osteoarthritic Osteoblasts
- M. Tofiño-Vian, M. I. Guillén, M. D. Pérez del Caz, M. Castejón, M. Alcaraz
- Biology, MedicineOxidative Medicine and Cellular Longevity
- 5 November 2017
The results in cells stimulated with interleukin- (IL-) 1β indicate that conditioned medium, microvesicles, and exosomes from ASC downregulate senescence-associated β-galactosidase activity and the accumulation of γH2AX foci.
Conditioned Media from Adipose-Tissue-Derived Mesenchymal Stem Cells Downregulate Degradative Mediators Induced by Interleukin-1β in Osteoarthritic Chondrocytes
- J. Platas, M. I. Guillén, M. D. P. del Caz, F. Gomar, V. Mirabet, M. Alcaraz
- Biology, MedicineMediators of Inflammation
- 1 December 2013
The data demonstrate the chondroprotective actions of CM and provide support for further studies of this approach in joint disease.
Selectivity of Neutrophil 5‐Lipoxygenase and Cyclo‐oxygenase Inhibition by an Anti‐inflammatory Flavonoid Glycoside and Related Aglycone Flavonoids
- M. Moroney, M. Alcaraz, R. Forder, F. Carey, J. Hoult
- Biology, ChemistryThe Journal of pharmacy and pharmacology
- 1 November 1988
Analysis of 12 aglycone flavonoids showed that inhibitory potency and selectivity against 5‐lipoxygenase is conferred by the presence of 3′4′‐vicinal diol in ring B as part of a 3,4‐dihydroxycinnamoyl structure as proposed by others and by incorporation of additional hydroxyl substituents.
Oxidative stress, autophagy, epigenetic changes and regulation by miRNAs as potential therapeutic targets in osteoarthritis.
Influence of a series of natural flavonoids on free radical generating systems and oxidative stress.
- M. Sanz, M. Ferrándiz, M. Alcaraz
- Biology, ChemistryXenobiotica; the fate of foreign compounds in…
- 1 July 1994
Treatment of mice with scutellarein, hispidulin, nepetin and kaempferol-3-O-galactoside after bromobenzene intoxication decreased serum glumate-pyruvate transaminase activity, although only the last flavonoid was able to significantly reduce hepatic lipid peroxidation products and to increase the reduced glutathione level.