Skip to search formSkip to main contentSkip to account menu

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

The MISEV2018 guidelines include tables and outlines of suggested protocols and steps to follow to document specific EV-associated functional activities, and a checklist is provided with summaries of key points.
View on Taylor & Francis (opens in a new tab)

Transcription Factor NRF2 as a Therapeutic Target for Chronic Diseases: A Systems Medicine Approach

NRF2 represents one of the first targets fully embraced by classic and systems medicine approaches to facilitate both drug development and drug repurposing by focusing on a set of disease phenotypes that appear to be mechanistically linked.
View on Publisher (opens in a new tab)

Microvesicles from Human Adipose Tissue-Derived Mesenchymal Stem Cells as a New Protective Strategy in Osteoarthritic Chondrocytes

The data support the interest of AD-MSC extracellular vesicles to develop new therapeutic approaches in joint conditions and show the reduction of inflammatory and catabolic mediators could be the consequence of a lower activation of nuclear factor-κB and activator protein-1.
View on PubMed (opens in a new tab)

Co-regulation between cyclo-oxygenase-2 and inducible nitric oxide synthase expression in the time-course of murine inflammation

The results indicate that PGE2 and NO may play in vivo mutual modulatory roles in the inflammatory response caused by zymosan injection into the mouse air pouch, a suitable model to study drugs acting on those pathways.
View on Springer (opens in a new tab)

The carbon monoxide‐releasing molecule CORM‐2 inhibits the inflammatory response induced by cytokines in Caco‐2 cells

This study has investigated whether tricarbonyl dichloro ruthenium(II) dimer (CORM‐2) can control the inflammatory response induced by cytokines in a human colonic epithelial cell line, Caco‐2.
View on Wiley (opens in a new tab)

Extracellular Vesicles from Adipose-Derived Mesenchymal Stem Cells Downregulate Senescence Features in Osteoarthritic Osteoblasts

The results in cells stimulated with interleukin- (IL-) 1β indicate that conditioned medium, microvesicles, and exosomes from ASC downregulate senescence-associated β-galactosidase activity and the accumulation of γH2AX foci.
View PDF (opens in a new tab)

Conditioned Media from Adipose-Tissue-Derived Mesenchymal Stem Cells Downregulate Degradative Mediators Induced by Interleukin-1β in Osteoarthritic Chondrocytes

The data demonstrate the chondroprotective actions of CM and provide support for further studies of this approach in joint disease.
View PDF (opens in a new tab)

Selectivity of Neutrophil 5‐Lipoxygenase and Cyclo‐oxygenase Inhibition by an Anti‐inflammatory Flavonoid Glycoside and Related Aglycone Flavonoids

Analysis of 12 aglycone flavonoids showed that inhibitory potency and selectivity against 5‐lipoxygenase is conferred by the presence of 3′4′‐vicinal diol in ring B as part of a 3,4‐dihydroxycinnamoyl structure as proposed by others and by incorporation of additional hydroxyl substituents.
View on Wiley (opens in a new tab)

Oxidative stress, autophagy, epigenetic changes and regulation by miRNAs as potential therapeutic targets in osteoarthritis.

View on PubMed (opens in a new tab)

Influence of a series of natural flavonoids on free radical generating systems and oxidative stress.

Treatment of mice with scutellarein, hispidulin, nepetin and kaempferol-3-O-galactoside after bromobenzene intoxication decreased serum glumate-pyruvate transaminase activity, although only the last flavonoid was able to significantly reduce hepatic lipid peroxidation products and to increase the reduced glutathione level.
View on PubMed (opens in a new tab)
...
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)