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Anti-inflammatory and analgesic activity of a novel inhibitor of microsomal prostaglandin E synthase-1 expression.
The data suggest that inhibition of mPGES-1 protein expression in acute and chronic inflammatory models by BTH, could provide a potential therapeutic target and a pharmacological tool to discern the role of the inducible enzymes COX-2 and mPGes-1 in inflammatory pathologies. Expand
Synthesis and pharmacological evaluation of a selected library of new potential anti-inflammatory agents bearing the gamma-hydroxybutenolide scaffold: a new class of inhibitors of prostanoid
A promising inhibitor of prostanoid production acting by in vitro and in vivo selective modulation of microsomal prostaglandin E synthase 1 expression is discovered. Expand
Effects of FR235222, a novel HDAC inhibitor, in proliferation and apoptosis of human leukaemia cell lines: role of annexin A1.
Results suggest that ANXA1 expression may mediate cycle arrest induced by low dosesFR235222, whereas apoptosis induced by high doses FR235222 is associated to ANxA1 processing. Expand
Dactylolide, a New Cytotoxic Macrolide from the Vanuatu SpongeDactylospongia sp.
Dactylolide (1), a new cytotoxic 20-membered macrolide, was isolated from a marine sponge of the genus Dactylospongia collected off the coast of the Vanuatu islands. It co-occurred with other knownExpand
Dragmacidin F: A New Antiviral Bromoindole Alkaloid from the Mediterranean Sponge Halicortex sp.
Abstract A new bromoindole alkaloid, named dragmacidin F ( 1 ) and structurally related to other dragmacidins previously described, was isolated from a marine sponge of the genus Halicortex collectedExpand
Novel HIV-inhibitory halistanol sulfates F-H from a marine sponge, Pseudoaxinissa digitata.
Three new steroid sulfates 2-4 related to halistanol sulfate were isolated along with the known halistanl sulfate C from the marine sponge Pseudoaxinissa digitata and proved to be cytoprotective against HIV. Expand
Chemistry and biology of chromatin remodeling agents: state of art and future perspectives of HDAC inhibitors.
This review outlines the chemistry of natural and synthetic agents endowed with the ability to interfere with biological function, with a particular emphasis on histone deacetylase (HDAC) inhibitors. Expand
Further brominated bis- and tris-indole alkaloids from the deep-water New Caledonian marine sponge Orina Sp.
Two tris-indole alkaloids have been isolated for the first time from a marine source, the New Caledonian sponge, and showed anti-serotonin activity and a strong affinity for somatostatin and neuropeptide Y receptors in receptor-binding assays. Expand