Share This Author
Synthesis and pharmacological evaluation of a selected library of new potential anti-inflammatory agents bearing the gamma-hydroxybutenolide scaffold: a new class of inhibitors of prostanoid…
- M. D. Guerrero, M. Aquino, L. Gomez‐Paloma
- Biology, ChemistryJournal of medicinal chemistry
- 4 April 2007
A promising inhibitor of prostanoid production acting by in vitro and in vivo selective modulation of microsomal prostaglandin E synthase 1 expression is discovered.
Anti-inflammatory and analgesic activity of a novel inhibitor of microsomal prostaglandin E synthase-1 expression.
Chemistry and biology of chromatin remodeling agents: state of art and future perspectives of HDAC inhibitors.
- M. Rodriquez, M. Aquino, I. Bruno, G. de Martino, M. Taddei, L. Gomez‐Paloma
- Biology, ChemistryCurrent medicinal chemistry
- 31 March 2006
This review outlines the chemistry of natural and synthetic agents endowed with the ability to interfere with biological function, with a particular emphasis on histone deacetylase (HDAC) inhibitors.
Chemistry and biology of anti-inflammatory marine natural products: molecules interfering with cyclooxygenase, NF-kappaB and other unidentified targets.
Marine natural products (MNP) have brought a collection of novel molecular entities displaying ability to target COX1/COX2, NF-kappaB or acting through molecular mechanisms yet-to-be-discovered, which will be grouped on the basis of their bio-molecular targets.
Toward the Discovery of New Agents Able to Inhibit the Expression of Microsomal Prostaglandin E Synthase‐1 Enzyme as Promising Tools in Drug Development
The biological effects of some structural changes of the γ‐hydroxybutenolide 2 led to the identification of three strictly correlated compounds 14g, 16g, and 18 with higher inhibitory potency on PGE2 production on mouse macrophage cell line RAW264.7 through the selective modulation of mPGES‐1 enzyme expression.
Natural and Unnatural A-seco Terpenes from Pulegone: Synthesis of Galbanic Acid and Marneral Revisited
We describe herein an improved chiral-pool strategy for assembling the core structure 3 (both antipodes) of various A-seco terpenoids that have allowed us to prepare natural galbanic acid [(–)-1]…
Total synthesis and structural confirmation of ent-galbanic acid and marneral.
The relative configurations of (+)- 1 and (+)- 2 were unambiguously established by X-ray crystallographic analysis of the precursors 11a and 20, with the absolute configuration ensuing from their derivation from R-pulegone.
Enantioselective synthesis of iridal, the parent molecule of the iridal triterpenoid class.
The monocyclic triterpene iridal 1 (parent molecule) is synthesized by an approach that allows access for several representatives of the iridal family as well as diversely substituted analogues. The…
Structural revision of halipeptins: Synthesis of the thiazoline unit and isolation of halipeptin C
Development of a second generation of inhibitors of microsomal prostaglandin E synthase 1 expression bearing the gamma-hydroxybutenolide scaffold.