peptidase activity

Known as: peptide hydrolase activity, hydrolase, acting on peptide bonds, proteinase activity 
Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino… (More)
National Institutes of Health

Papers overview

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Highly Cited
2005
Highly Cited
2005
Hepatitis C virus (HCV) is a major human pathogen that infects 170 million people. A hallmark of HCV is its ability to establish… (More)
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Highly Cited
2002
Highly Cited
2002
To identify human proteins that bind to the Smac and caspase-9 binding pocket on the baculoviral inhibitor of apoptosis protein… (More)
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Highly Cited
2002
Highly Cited
2002
In an effort to better understand the phenomenon of lipotoxicity in human beta-cells, we evaluated the effects of 48-h preculture… (More)
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Highly Cited
2000
Highly Cited
2000
In yeast, anaphase depends on cohesin cleavage. How anaphase is controlled in vertebrates is unknown because their cohesins… (More)
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Highly Cited
1998
Highly Cited
1998
Caspases are intracellular proteases that function as initiators and effectors of apoptosis. The kinase Akt and p21-Ras, an Akt… (More)
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Highly Cited
1998
Highly Cited
1998
BACKGROUND Thrombotic thrombocytopenic purpura and the hemolytic-uremic syndrome are severe microvascular disorders of platelet… (More)
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Highly Cited
1997
Highly Cited
1997
Nitric oxide (NO) has emerged as an important endogenous inhibitor of apoptosis, and here we report that NO prevents hepatocyte… (More)
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Highly Cited
1996
Highly Cited
1996
Expression of BAX, without another death stimulus, proved sufficient to induce a common pathway of apoptosis. This included the… (More)
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Highly Cited
1995
Highly Cited
1995
Lactacystin is a Streptomyces metabolite that inhibits cell cycle progression and induces neurite outgrowth in a murine… (More)
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Highly Cited
1992
Highly Cited
1992
CLOSTRIDIAL neurotoxins, including tetanus toxin and the seven serotypes of botulinum toxin (A–G), are produced as single chains… (More)
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