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Endocrine-disrupting chemicals: an Endocrine Society scientific statement.
The evidence that endocrine disruptors have effects on male and female reproduction, breast development and cancer, prostate cancer, neuroendocrinology, thyroid, metabolism and obesity, and cardiovascular endocrinology is presented.
The insulin-related ovarian regulatory system in health and disease.
The Insulin-Related Ovarian Regulatory System: Implications for Therapy and Therapeutic use are summarized.
Molecular phenotyping of human endometrium distinguishes menstrual cycle phases and underlying biological processes in normo-ovulatory women.
Endometrial samples obtained by two different sampling techniques from subjects who are as normal as possible in a human study and including those with unknown histology, can be classified by their molecular signatures and correspond to known phases of the menstrual cycle with identical results using two independent analytical methods.
Clinical practice. Endometriosis.
- L. Giudice
- MedicineThe New England journal of medicine
- 24 June 2010
A healthy 25-year-old woman presents with worsening dysmenorrhea, pain of recent onset in the left lower quadrant, and dyspareunia. She has regular menstrual cycles, and her last menstrual period was…
Global gene profiling in human endometrium during the window of implantation.
Global gene expression during the window of implantation (peak E2 and progesterone levels) in well characterized human endometrial biopsies timed to the LH surge is investigated, compared with the late proliferative phase ( peak E2 level) of the menstrual cycle.
Gene expression analysis of endometrium reveals progesterone resistance and candidate susceptibility genes in women with endometriosis.
Global gene expression analysis of endometrium from women with and without moderate/severe stage endometriosis and compared the gene expression signatures across various phases of the menstrual cycle provided a framework for further investigations on causality and mechanisms underlying attenuated progesterone response inendometrium of women with endometRIosis.
Insulin-like Growth Factor Binding Protein-1: Recent Findings and New Directions
- Phillip D. K. Lee, L. Giudice, C. Conover, D. Powell
- Biology, MedicineProceedings of the Society for Experimental…
- 1 December 1997
Similarities between the hlGFBP-1 and phosphoenolpyruvate kinase (PEPCK) promoters, including regions conferring insulin, glucocorticoid, and cyclic adenosine-monophosphate responses, are consistent with the previous hypothesis that IGF BP-1 is involved in regulation of glucose metabolism.
Pathogenesis and pathophysiology of endometriosis.
Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome.
Clomiphene is superior to metformin in achieving live birth in infertile women with the polycystic ovary syndrome, although multiple birth is a complication.
Microbes on the human vaginal epithelium
- R. Hyman, M. Fukushima, Lisa Diamond, J. Kumm, L. Giudice, Ronald W. Davis
- Biology, MedicineProceedings of the National Academy of Sciences…
- 23 May 2005
Using solely a gene-based procedure, PCR amplification of the 16S ribosomal RNA gene coupled with very deep sequencing of the amplified products, the microbes on 20 human vaginal epithelia of healthy…