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Proteolytic Enzyme

Known as: proteolytic, Proteinase, Protease 
Enzymes acting on peptide bonds. EC 3.4.-
National Institutes of Health

Related topics

Related topics

40 relations
ATG4C protein, humanActivated Caspase-3BAP1 protein, humanCAPN1 protein, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2012
Review
2012
Cardiovascular biology of the incretin system.
Glucagon-like peptide-1 (GLP-1) is an incretin hormone that enhances glucose-stimulated insulin secretion and exerts direct and… 
Review
2009
Review
2009
The inflammatory & neurodegenerative (I&ND) hypothesis of depression: leads for future research and new drug developments in depression
Despite extensive research, the current theories on serotonergic dysfunctions and cortisol hypersecretion do not provide… 
Highly Cited
2005
Highly Cited
2005
(2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine: a potent, orally active dipeptidyl peptidase IV inhibitor for the…
A novel series of beta-amino amides incorporating fused heterocycles, i.e., triazolopiperazines, were synthesized and evaluated… 
Review
2004
Review
2004
Evolutionary families of peptidase inhibitors.
The proteins that inhibit peptidases are of great importance in medicine and biotechnology, but there has never been a… 
Highly Cited
2003
Highly Cited
2003
1-[[(3-hydroxy-1-adamantyl)amino]acetyl]-2-cyano-(S)-pyrrolidine: a potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitor with antihyperglycemic properties.
Dipeptidyl peptidase IV (DPP-IV) inhibition has the potential to become a valuable therapy for type 2 diabetes. The synthesis and… 
Highly Cited
2002
Highly Cited
2002
Intramembrane proteolysis promotes trafficking of hepatitis C virus core protein to lipid droplets
Hepatitis C virus (HCV) is the major causative pathogen associated with liver cirrhosis and hepatocellular carcinoma. The virus… 
Review
1996
Review
1996
Structure and functions of the 20S and 26S proteasomes.
The proteasome is an essential component of the ATP-dependent proteolytic pathway in eukaryotic cells and is responsible for the… 
Highly Cited
1995
Highly Cited
1995
Male–female differences in fertility and blood pressure in ACE-deficient mice
ANGIOTENSIN-CONVERTING enzyme (ACE) is a dipeptidyl carboxy-peptidase that generates the vasoconstricting peptide angiotensin II… 
Review
1991
Review
1991
Calcium-activated neutral protease (calpain) system: structure, function, and regulation.
Review
1990
Review
1990
Lipoproteins in bacteria
Covalent modification of membrane proteins with lipids appears to be ubiquitous in all living cells. The major outer membrane… 
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