paromamine
National Institutes of Health
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Aminoglycosides are antibiotic drugs that act through binding to rRNA. In the search for antimicrobial amphiphilic…
Aims: The 2‐deoxystreptamine‐containing aminoglycoside antibiotics (AGAs) constitute the largest subgroup of the aminoglycosides…
Aims: Paromamine is a vital and common intermediate in the biosynthesis of 4,5 and 4,6‐disubstituted 2‐deoxystreptamine (DOS…
The 2-deoxystreptamine and paromamine are two key intermediates in kanamycin biosynthesis. In the present study, pSK-2 and pSK-7…
several other RNA motifs form well-defined complexes with individual aminoglycosides, which makes these antibiotics excellent…
Natural aminoglycoside antibiotics recognize an internal loop of bacterial ribosomal‐decoding‐site RNA by binding to the deep…
Paromamine1>2) is a common and antibacterial moiety of paromomycin I and II, and kanamycin C, and was recently isolated3) from a…
Kanamycin and paromamine were inactivated in the presence of ATP and Mg++ by an enzyme solution obtained from E. coli carrying R…
6-deoxy-D-glucose moiety in kanamycin, phosphorylating the C-3 hydroxyl group of the same moiety in kanamycin, or phosphorylating…