Arglecin, a new microbial metabolite isolation and chemical structure.
- K. Tatsuta, T. Tsuchiya, T. Someno, S. Umezawa, H. Umezawa
- ChemistryJournal of antibiotics (Tokyo. )
- 1 November 1971
A new streptomycete metabolite named arglecin was isolated from the culture filtrates of the strains KA57-AG3, KB59-M1 and the other 11 strains by the screening of compounds with positive Wood and…
3',4'-dideoxy-kanamycin B active against kanamycin-resistant Escherichia coli and Pseudomonas aeruginosa.
- H. Umezawa, S. Umezawa, T. Tsuchiya, Y. Okazaki
- ChemistryJournal of antibiotics (Tokyo. )
- 25 July 1971
synthetic method showed antibacterial activity against E. colt 1629, 1630 carrying R factor and P. aeruginosa for which kanamycin showed no activity. In this communication, the application of a…
Synthesis of 3'-deoxykanamycin effective against kanamycin-resistant Escherichia coli and Pseudomonas aeruginosa.
- S. Umezawa, T. Tsuchiya, R. Muto, Y. Nishimura, H. Umezawa
- Chemistry, BiologyJournal of antibiotics (Tokyo. )
- 1 April 1971
The authors attempted, for the first approach, to prepare 3r-0-methylkanamycin (I) by a synthetic method, and suggested that blocking or removal of the hydroxyl group which is phosphorylated will give new compounds effective against the resistant organisms.
A novel synthesis of 2-deoxy-α-glycosides
- K. Tatsuta, K. Fujimoto, M. Kinoshita, S. Umezawa
- Chemistry
- 1 March 1977
KD16-U1, a new metabolite of Streptomyces: isolation and structural studies.
- K. Tatsuta, T. Tsuchiya, N. Mikami, S. Umezawa, H. Umezawa, H. Naganawa
- Engineering, ChemistryJournal of antibiotics (Tokyo. )
- 1 August 1974
A new metabolite, KD16-U1, has been isolated from the culture of Streptomyces filipinensis and has been found to be closely related to shikimic acid.
Fermentation of 3-amino-3-deoxy-D-glucose.
- S. Umezawa, K. Umino, S. Shibahara, M. Hamada, S. Omoto
- ChemistryJournal of antibiotics (Tokyo. )
- 1 November 1967
Total synthesis of the disaccharide of bleomycin, 2-0-(α-D-mannopyranosyl)-L-gulopyranose
- T. Tsuchiya, T. Miyake, S. Kageyama, S. Umezawa, H. Umezawa, T. Takita
- Chemistry
- 1981
Biological properties of ME2303 (FAD-104), a new anthracycline.
- S. Omoto, S. Kondo, S. Umezawa
- Chemistry, BiologyDrugs under experimental and clinical research
- 1988
From ECG changes, it seems that ME2303 did not show any effect on the heart in acute toxicity, and Mutagenicity was recognized as with ADM in the back-mutation test.
Studies on Antibiotics and Related Substances. VIII. Syntheses of the Two Enantiomorphs of 5-Methylenecyclopentanone-3-carboxylic Acid
- M. Kinoshita, S. Umezawa
- Chemistry
- 1 March 1959
1) The two diastereoisomeric mixtures (IIa and lIb) of 5-(dimethylaminomethyl)-cyclopentanone-3-carboxylic acid hydrochloride were synthesized from the two enantiomorphs of…
Recent advances in the synthesis of aminoglycoside antibiotics
- S. Umezawa
- Chemistry
- 1 May 1979
Abstract Aminoglycoside antibiotics have established an important position in medicine and synthetic chemistry in this field has recently been developed. A review is provided of general synthetic…
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