palbociclib

Known as: 6-Acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-8h-pyrido(2,3-d)pyrimidin-7-one, 6-acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-ylpyridin-2-ylamino)-8H-pyrido(2,3-d)pyrimidin-7-one, 6-acetyl-8-cyclopentyl-5-methyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}pyrido[2,3-d]pyrimidin-7(8H)-one 
An orally available cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity. Palbociclib selectively inhibits cyclin-dependent… (More)
National Institutes of Health

Papers overview

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Review
2017
Review
2017
Uncontrolled cell division is the hallmark of cancers. Full understanding of cell cycle regulation would contribute to promising… (More)
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Highly Cited
2016
Highly Cited
2016
BACKGROUND A phase 2 study showed that progression-free survival was longer with palbociclib plus letrozole than with letrozole… (More)
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Highly Cited
2016
Highly Cited
2016
BACKGROUND In the PALOMA-3 study, the combination of the CDK4 and CDK6 inhibitor palbociclib and fulvestrant was associated with… (More)
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Review
2016
Review
2016
Cyclins and cyclin-dependent protein kinases (CDKs) are important regulatory components that are required for cell cycle… (More)
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Highly Cited
2015
Highly Cited
2015
To the Editor: In the PALOMA3 study, Turner et al. (July 16 issue)1 report that the addition of palbociclib to fulvestrant… (More)
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Highly Cited
2015
Highly Cited
2015
PURPOSE The G1-S checkpoint of the cell cycle is frequently dysregulated in breast cancer. Palbociclib (PD0332991) is an oral… (More)
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Review
2015
Review
2015
Palbociclib (Ibrance®) is an oral, reversible, selective, small-molecule inhibitor of cyclin-dependent kinases (CDK) 4 and CDK6… (More)
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Highly Cited
2015
Highly Cited
2015
n engl j med 373;17 nejm.org october 22, 2015 1673 and we will be updating efficacy and safety data. The first updated data… (More)
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Review
2015
Review
2015
On February 3, 2015, the FDA granted accelerated approval to palbociclib (IBRANCE, Pfizer Inc.), an inhibitor of cyclin-dependent… (More)
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Highly Cited
2014
Highly Cited
2014
BACKGROUND Palbociclib (PD-0332991) is an oral, small-molecule inhibitor of cyclin-dependent kinases (CDKs) 4 and 6 with… (More)
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