PD 0332991

Known as: PD-0332991, PD-332991, PD0332991 
An orally available pyridopyrimidine-derived cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity. PD-0332991 selectively… (More)
National Institutes of Health

Papers overview

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Review
2017
Review
2017
Uncontrolled cell division is the hallmark of cancers. Full understanding of cell cycle regulation would contribute to promising… (More)
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Review
2014
Review
2014
INTRODUCTION The cyclin D-cyclin-dependent kinases 4 and 6 (CDK4/6)-retinoblastoma (Rb) pathway, governing the cell cycle… (More)
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Highly Cited
2014
Highly Cited
2014
BACKGROUND Palbociclib (PD-0332991) is an oral, small-molecule inhibitor of cyclin-dependent kinases (CDKs) 4 and 6 with… (More)
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2013
2013
Diffuse intrinsic pontine glioma (DIPG) is an incurable tumor that arises in the brainstem of children. To date there is not a… (More)
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Highly Cited
2012
Highly Cited
2012
PURPOSE To identify the dose-limiting toxicity (DLT) and maximum tolerated dose (MTD) of the first-in-class, oral CDK4/6… (More)
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Highly Cited
2011
Highly Cited
2011
Background:This phase I, open-label, first-in-human study determined dose-limiting toxicities (DLTs) and maximum tolerated dose… (More)
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Highly Cited
2010
Highly Cited
2010
Activation of cyclin-dependent kinases 4 and 6 (cdk4/6) occurs in the majority of glioblastoma multiforme (GBM) tumors, and… (More)
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Highly Cited
2009
Highly Cited
2009
Alterations in cell cycle regulators have been implicated in human malignancies including breast cancer. PD 0332991 is an orally… (More)
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Highly Cited
2008
Highly Cited
2008
Multiple myeloma (MM) remains incurable partly because no effective cell cycle-based therapy has been available to both control… (More)
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Highly Cited
2004
Highly Cited
2004
PD 0332991 is a highly specific inhibitor of cyclin-dependent kinase 4 (Cdk4) (IC50, 0.011 micromol/L) and Cdk6 (IC50, 0.016… (More)
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