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RNAi knockdown of Hop (Hsp70/Hsp90 organising protein) decreases invasion via MMP-2 down regulation.
We previously identified Hop as over expressed in invasive pancreatic cancer cell lines and malignant tissues of pancreatic cancer patients, suggesting an important role for Hop in the biology ofExpand
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Expression of multidrug resistance markers ABCB1 (MDR-1/P-gp) and ABCC1 (MRP-1) in renal cell carcinoma
BackgroundRenal cell carcinoma patients respond poorly to conventional chemotherapy, this unresponsiveness may be attributable to multidrug resistance (MDR). The mechanisms of MDR in renal cancer areExpand
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Alterations in integrin expression modulates invasion of pancreatic cancer cells
BackgroundFactors mediating the invasion of pancreatic cancer cells through the extracellular matrix (ECM) are not fully understood.MethodsIn this study, sub-populations of the human pancreaticExpand
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Aldehyde dehydrogenase 1A1 and gelsolin identified as novel invasion-modulating factors in conditioned medium of pancreatic cancer cells.
Conditioned medium (CM) from clonal sub-populations of the pancreatic cancer cell line, MiaPaCa-2 with differing invasive abilities, were examined for their effect on in vitro invasion. ConditionedExpand
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EGFR and HER2 inhibition in pancreatic cancer
SummaryThe aim of this study was to investigate the effect of lapatinib, a selective inhibitor of EGFR/HER2 tyrosine kinases, on pancreatic cancer cell lines both alone and in combination withExpand
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Identification of pancreatic cancer invasion-related proteins by proteomic analysis
BackgroundMarkers of pancreatic cancer invasion were investigated in two clonal populations of the cell line, MiaPaCa-2, Clone #3 (high invasion) and Clone #8 (low invasion) using proteomic profilingExpand
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Challenges of drug resistance in the management of pancreatic cancer
The current treatment of choice for metastatic pancreatic cancer involves single-agent gemcitabine or a combination of gemcitabine with capecitabine or erlotinib (a tyrosine kinase inhibitor). OnlyExpand
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Membrane transport proteins in human melanoma: associations with tumour aggressiveness and metastasis
Background:Malignant melanoma, generally described as incurable, is notoriously refractory to chemotherapy. The mechanisms contributing to this have not yet been defined and the contributions of drugExpand
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Temperature sensitivity of an atmospheric Raman lidar system based on an XeF excimer laser.
The temperature sensitivity of Raman backscattering from atmospheric nitrogen, oxygen, and water vapor is considered over the range of temperatures expected in the troposphere. These results areExpand
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Kinase inhibitor screening identifies CDK4 as a potential therapeutic target for melanoma
Despite recent advances in targeted therapies and immunotherapies metastatic melanoma remains only rarely curable. The objective of the present study was to identify novel therapeutic targets forExpand
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