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p14ARF Protein

Known as: Cdkn2a(p14ARF), Tumor Suppressor Protein p14ARF, Tumor Suppressor Protein p14ARF [Chemical/Ingredient] 
A gene product of the p16 tumor suppressor gene (GENES, P16). It antagonizes the function of MDM2 PROTEIN (which regulates P53 TUMOR SUPPRESSOR… 
National Institutes of Health

Related topics

Related topics

13 relations
CDKN2A geneCDKN2A wt AlleleCyclin-Dependent Kinase Inhibitor p16In Blood

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p19(ARF) protein, mouse

Papers overview

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Highly Cited
2007
Highly Cited
2007
Oxidative stress and DNA hypermethylation status in renal cell carcinoma arising in patients on dialysis
Renal cell carcinoma (RCC) is more frequently observed in patients on dialysis than in patients with normal renal function… 
Review
2006
Review
2006
DNA damage, p14ARF, Nucleophosmin (NPM/B23), and cancer
The p53/p14ARF/mdm2 stress response pathway plays a central role in mediating cellular responses to oncogene activation, genome… 
Highly Cited
2005
Highly Cited
2005
A mutation hotspot at the p14ARF splice site
Germline mutations of CDKN2A that affect the p16INK4a transcript have been identified in numerous melanoma pedigrees worldwide… 
Highly Cited
2005
Highly Cited
2005
p53 regulation and function in renal cell carcinoma.
Loss of p53 function is a critical event in tumor evolution. This occurs through a range of molecular events, typically a… 
Highly Cited
2004
Highly Cited
2004
High‐density methylation of p14ARF and p16INK4A in Epstein‐Barr virus–associated gastric carcinoma
Promoter hypermethylation of various tumor‐related genes is extremely frequent in gastric carcinoma (GC) associated with Epstein… 
Highly Cited
2003
Highly Cited
2003
Promoter hypermethylation of multiple genes in astrocytic gliomas.
Promoter hypermethylation represents a primary mechanism in the inactivation of tumor suppressor genes during tumorigenesis. To… 
Highly Cited
2003
Highly Cited
2003
CDKN2A, CDKN2B and p14 ARF are frequently and differentially methylated in ependymal tumours
Ependymal tumours are histologically and clinically varied lesions. Numerical abnormalities of chromosome 9 are frequently… 
Highly Cited
2001
Highly Cited
2001
Mutational analysis of N-ras, p53, p16INK4a, p14ARF and CDK4 genes in primary human malignant mesotheliomas.
Nineteen specimens from primary human malignant mesotheliomas obtained from 19 patients were screened for activating point… 
Highly Cited
2000
Highly Cited
2000
Two arginine rich domains in the p14ARF tumour suppressor mediate nucleolar localization
The INK4a/ARF locus encodes two distinct tumour suppressors, p16INK4a and p14ARF, that regulate cell cycle progression via the… 
Highly Cited
1999
Highly Cited
1999
Inactivation of the INK4A/ARF locus frequently coexists with TP53 mutations in non-small cell lung cancer
Inactivation of the P16 (INK4A)/retinoblastoma (RB) or TP53 biochemical pathway is frequent event in most human cancers. Recent… 
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