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osimertinib

Known as: Mereletinib, N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide 
A third-generation, orally available, irreversible, mutant-selective, epidermal growth factor receptor (EGFR) inhibitor, with potential… 
National Institutes of Health

Related topics

Related topics

11 relations

Narrower (3)

AZD9291Tagrissoosimertinib mesylate

Broader (3)

Antineoplastic AgentsPiperazinesProtein Kinase Inhibitors
Breast Cancer Resistance Protein Inhibitors [MoA]Kinase Inhibitors [MoA]NCIt Antineoplastic Agent TerminologyReceptor Tyrosine Kinase Inhibition

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Plasma screening for the T790M mutation of EGFR and phase 2 study of osimertinib efficacy in plasma T790M–positive non–small cell lung cancer: West Japan Oncology Group 8815L/LPS study
Liquid biopsy allows the identification of patients whose tumors harbor specific mutations in a minimally invasive manner. No… 
2020
2020
Osimertinib in non-small cell lung cancer (NSCLC) with atypical EGFR activating mutations: A retrospective multicenter study.
9570 Background: Osimertinib (osi) is a 3rd generation EGFR tyrosine kinase inhibitor (TKI) approved for first line (1L… 
2019
2019
The presence and variant allele fraction of EGFR mutations in ctDNA and development of resistance.
2018
2018
Phase II trial of gefitinib plus pemetrexed after relapse using first-line gefitinib in patients with non-small cell lung cancer harboring EGFR gene mutations.
2018
2018
Primary and acquired EGFR T790M-mutant NSCLC patients identified by routine mutation testing show different characteristics but may both respond to osimertinib treatment.
Review
2018
Review
2018
Resistance to epidermal growth factor receptor tyrosine kinase inhibitors, T790M, and clinical trials.
Tumours with sensitizing mutations in the EGFR gene constitute a distinct molecular subgroup of non-small-cell lung cancers… 
Review
2017
Review
2017
Osimertinib for EGFR T790M mutation-positive non-small cell lung cancer
ABSTRACT Introduction: Significant advances have been made since the development of epidermal growth factor receptor tyrosine… 
2017
2017
The activation of SRC family kinases and focal adhesion kinase with the loss of the amplified, mutated EGFR gene contributes to the resistance to afatinib, erlotinib and osimertinib in human lung…
Second- and third-generation inhibitors of epidermal growth factor receptor (EGFR) tyrosine kinase activity (EGFR-TKIs) are… 
2017
2017
Detection of epidermal growth factor receptor gene T790M mutation in cytology samples using the cobas® EGFR mutation test.
2017
2017
Re-biopsy after relapse of targeted therapy. T790M after epidermal growth factor mutation, where and why based on a case series
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