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Endothelial barrier function is an essential and tightly regulated process that ensures proper compartmentalization of the… Expand Olprinone, a specific phosphodiesterase III inhibitor, and corforsin daropate, a direct adenylate cyclase activator, are now… Expand PURPOSE
Acute respiratory distress syndrome is characterized by neutrophil accumulation in the lungs and the activation of… Expand Cerebral blood flow (CBF) is reduced in heart failure (HF). For the treatment of acute HF, a phosphodiesterase-3 inhibitor… Expand Olprinone is a newly developed phosphodiesterase III inhibitor characterized by several properties. First, olprinone has positive… Expand Background—Phosphodiesterase III inhibitors (PDEIII-Is) improve the hemodynamic status of heart failure via inotropic… Expand Objective: To measure the hepatic venous oxygen saturation in patients after cardiac surgery and to compare the effects of… Expand Background: Increasing evidence indicates that amrinone, a phosphodiesterase fraction III (PDE‐III) inhibitor, has relative… Expand The effect of topical administration of phosphodiesterase (PDE) 3 inhibitors on the airway is not clear. In order to examine the… Expand We investigated the inotropic effect of SCH00013 (4, 5-dihydro-6-[1-[2-hydroxy-2-(4-cyanophenyl)ethyl]-1,2,5, 6-tetrahydropyrido… Expand