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olprinone

Known as: 1,2-dihydro-6-methyl-2-oxo-5-(imidazo(1,2-a)pyridin-6-yl)-3-pyridinecarbonitrile 
National Institutes of Health

Related topics

Related topics

6 relations

Broader (4)

Cardiotonic AgentsImidazolesPhosphodiesterase 3 InhibitorsPyridones

Narrower (2)

E 1020loprinone hydrochloride

Papers overview

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2007
2007
The effects of vasoactive agents, platelet agonists and anticoagulation on thrombelastography
Background:  Platelet activation is a critical step in primary hemostasis and clot formation. We tested a hypothesis that… 
2007
2007
Effects of olprinone, a phosphodiesterase III inhibitor, on ischemic acute renal failure
Objective:  Renal ischemic reperfusion injury (IRI) is unavoidable and is still one of the major problems in renal… 
2003
2003
Improvement of Cerebral Blood Flow by Olprinone, a Phosphodiesterase-3 Inhibitor, in Mild Heart Failure
Cerebral blood flow (CBF) is reduced in heart failure (HF). For the treatment of acute HF, a phosphodiesterase-3 inhibitor… 
2003
2003
Bronchodilator effects of intravenous olprinone, a phosphodiesterase 3 inhibitor, with and without aminophylline in asthmatic patients.
AIMS There is no evidence demonstrating the clinical usefulness of phosphodiesterase (PDE) inhibitors in the treatment of asthma… 
2003
2003
Repetitive preischemic infusion of phosphodiesterase III inhibitor olprinone elicits cardioprotective effects in the failing heart after myocardial infarction
Beta-adrenergic (BA) signaling including cAMP-protein kinase A (PKA) pathway has been implicated in the mechanism of ischemic… 
2001
2001
A Comparison of the Relaxant Effects of Olprinone and Aminophylline on Methacholine-Induced Bronchoconstriction in Dogs
IV aminophylline, a nonselective phosphodiesterase (PDE) inhibitor, is often used to treat an asthma attack during anesthesia… 
2000
2000
A Comparison of the Spasmolytic Effects of Olprinone and Aminophylline on Serotonin-Induced Pulmonary Hypertension and Bronchoconstriction With or Without &bgr;-Blockade in Dogs
In the present study in dogs, we compared with aminophylline the spasmolytic effects of olprinone, a novel phosphodiesterase 3… 
2000
2000
Effect of olprinone, phosphodiesterase III inhibitor, on cerebral blood flow assessed with technetium-99m-ECD SPECT.
Few clinical reports exist regarding the effects of phosphodiesterase III inhibitors on cerebral arteries. Therefore we used a… 
Highly Cited
1999
Highly Cited
1999
Bronchodilator effect of inhaled olprinone, a phosphodiesterase 3 inhibitor, in asthmatic patients.
The effect of topical administration of phosphodiesterase (PDE) 3 inhibitors on the airway is not clear. In order to examine the… 
1998
1998
A novel cardiotonic agent SCH00013 acts as a Ca++ sensitizer with no chronotropic activity in mammalian cardiac muscle.
We investigated the inotropic effect of SCH00013 (4, 5-dihydro-6-[1-[2-hydroxy-2-(4-cyanophenyl)ethyl]-1,2,5, 6-tetrahydropyrido… 
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