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olprinone

Known as: 1,2-dihydro-6-methyl-2-oxo-5-(imidazo(1,2-a)pyridin-6-yl)-3-pyridinecarbonitrile 
National Institutes of Health

Related topics

Related topics

6 relations

Broader (4)

Cardiotonic AgentsImidazolesPhosphodiesterase 3 InhibitorsPyridones

Narrower (2)

E 1020loprinone hydrochloride

Papers overview

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2013
2013
Short-term cardiovascular effects of selective phosphodiesterase 3 inhibitor olprinone versus non-selective phosphodiesterase inhibitor aminophylline in a meconium-induced acute lung injury.
Various anti-inflammatory drugs have been used for treatment of neonatal meconium aspiration syndrome (MAS). As their adverse… 
2008
2008
Olprinone decreases elevated concentrations of cytokine-induced neutrophil chemoattractant-1 in septic rats
PurposeThe diaphragm is one of the organs directly affected by abdominal sepsis. Evidence suggests that sepsis induces… 
2007
2007
The effects of vasoactive agents, platelet agonists and anticoagulation on thrombelastography
Background:  Platelet activation is a critical step in primary hemostasis and clot formation. We tested a hypothesis that… 
2007
2007
Selective inhibitors for phosphodiesterase 3 and 4 in antigen-induced increase of cough reflex sensitivity in guinea pigs.
2007
2007
Effects of olprinone, a phosphodiesterase III inhibitor, on ischemic acute renal failure
Objective:  Renal ischemic reperfusion injury (IRI) is unavoidable and is still one of the major problems in renal… 
2003
2003
Repetitive preischemic infusion of phosphodiesterase III inhibitor olprinone elicits cardioprotective effects in the failing heart after myocardial infarction
Beta-adrenergic (BA) signaling including cAMP-protein kinase A (PKA) pathway has been implicated in the mechanism of ischemic… 
2003
2003
Olprinone, a Phosphodiesterase III Inhibitor, Reduces Gut Mucosal Injury and Portal Endotoxin Level during Acute Hypoxia in Rabbits
Background Preservation of gut integrity has become a therapeutic goal to obviate bacterial translocation in the critically ill… 
2001
2001
Use of olprinone, a phosphodiesterase III inhibitor, in an asthmatic patient
Phosphodiesterase (PDE) III exists in airway smooth muscles. In addition, PDEIII inhibitors have been suggested to relax airway… 
2000
2000
A Comparison of the Spasmolytic Effects of Olprinone and Aminophylline on Serotonin-Induced Pulmonary Hypertension and Bronchoconstriction With or Without &bgr;-Blockade in Dogs
In the present study in dogs, we compared with aminophylline the spasmolytic effects of olprinone, a novel phosphodiesterase 3… 
2000
2000
Effect of olprinone, phosphodiesterase III inhibitor, on cerebral blood flow assessed with technetium-99m-ECD SPECT.
Few clinical reports exist regarding the effects of phosphodiesterase III inhibitors on cerebral arteries. Therefore we used a… 
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