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Pyridones

Known as: Pyridones [Chemical/Ingredient], pyridinone, Pyridinones 
Pyridine derivatives with one or more keto groups on the ring.
National Institutes of Health

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1,4-dimethyl-2-pyridinone2,6-dimethyl-3-oxypyridine3,5,6-trichloro-2-pyridinol3-acetoxy-2-pyridone
In Bloodagonistsantagonists & inhibitorschemical synthesis

Papers overview

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2014
2014
Pyridinium-fused pyridinone: a novel "turn-on" fluorescent chemodosimeter for cyanide.
A new chemodosimeter based on pyridinium-fused pyridinone iodide (PI) has been obtained through a "clean reaction" method. This… 
Highly Cited
2011
Highly Cited
2011
An Improved Catalyst Architecture for Rhodium (III) Catalyzed C-H Activation and its Application to Pyridone Synthesis.
We have developed a method for preparing pyridones from the coupling reaction of acrylamides and alkynes with either… 
2005
2005
Halogenated and isosteric cytisine derivatives with increased affinity and functional activity at nicotinic acetylcholine receptors.
2001
2001
Structure-Function Investigation of the Interaction of 1- and 2-Substituted 3-Hydroxypyridin-4-ones with 5-Lipoxygenase and Ribonucleotide Reductase*
The structural and physiochemical properties of 3-hydroxypyridin-4-one chelators (HPOs) which influence inhibition of the iron… 
1999
1999
3-Acetyl-5-acylpyridin-2(1H)-ones and 3-acetyl-7,8-dihydro-2,5(1H,6H)-quinolinediones: synthesis, cardiotonic activity and computational studies.
Highly Cited
1998
Highly Cited
1998
Efficacious, orally bioavailable thrombin inhibitors based on 3-aminopyridinone or 3-aminopyrazinone acetamide peptidomimetic templates.
We have addressed the key deficiency of noncovalent pyridinone acetamide thrombin inhibitor L-374,087 (1), namely, its modest… 
Highly Cited
1995
Highly Cited
1995
A new series of pyridinone derivatives as potent non-nucleoside human immunodeficiency virus type 1 specific reverse transcriptase inhibitors.
4-(Arylthio)-pyridin-2(1H)-ones variously substituted in their 3-, 5-, and 6-positions have been synthesized as a new series of 1… 
1993
1993
Inhibition of HIV-1 reverse transcriptase by pyridinone derivatives. Potency, binding characteristics, and effect of template sequence.
Highly Cited
1992
Highly Cited
1992
Identification of the human immunodeficiency virus reverse transcriptase residues that contribute to the activity of diverse nonnucleoside inhibitors
The reverse transcriptase (RT) of human immunodeficiency virus type 1 (HIV-1) is potently inhibited by a structurally diverse… 
Highly Cited
1973
Highly Cited
1973
Purification and properties of the aldehyde oxidases from hog and rabbit livers.
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