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Pyridones

Known as: Pyridones [Chemical/Ingredient], pyridinone, Pyridinones 
Pyridine derivatives with one or more keto groups on the ring.
National Institutes of Health

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1,4-dimethyl-2-pyridinone2,6-dimethyl-3-oxypyridine3,5,6-trichloro-2-pyridinol3-acetoxy-2-pyridone
In Bloodagonistsantagonists & inhibitorschemical synthesis

Papers overview

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Highly Cited
2014
Highly Cited
2014
Cobalt(II) complexes with the antimicrobial drug enrofloxacin: structure, antimicrobial activity, DNA- and albumin-binding.
Highly Cited
2011
Highly Cited
2011
An Improved Catalyst Architecture for Rhodium (III) Catalyzed C-H Activation and its Application to Pyridone Synthesis.
We have developed a method for preparing pyridones from the coupling reaction of acrylamides and alkynes with either… 
Highly Cited
2011
Highly Cited
2011
Synthesis of 3,4-dihydropyridin-2(1H)-ones and 3,4-dihydro-2H-pyrans via Four-component reactions of aromatic aldehydes, cyclic 1,3-carbonyls, arylamines, and dimethyl acetylenedicarboxylate.
A protocol has been developed for the efficient synthesis of structurally diverse 3,4-dihydropyridin-2(1H)-ones and 3,4-dihydro… 
Highly Cited
2009
Highly Cited
2009
Enantioselective rhodium-catalyzed [2 + 2 + 2] cycloadditions of terminal alkynes and alkenyl isocyanates: mechanistic insights lead to a unified model that rationalizes product selectivity.
This manuscript describes the development and scope of the asymmetric rhodium-catalyzed [2 + 2 + 2] cycloaddition of terminal… 
Highly Cited
1998
Highly Cited
1998
Efficacious, orally bioavailable thrombin inhibitors based on 3-aminopyridinone or 3-aminopyrazinone acetamide peptidomimetic templates.
We have addressed the key deficiency of noncovalent pyridinone acetamide thrombin inhibitor L-374,087 (1), namely, its modest… 
Highly Cited
1995
Highly Cited
1995
A new series of pyridinone derivatives as potent non-nucleoside human immunodeficiency virus type 1 specific reverse transcriptase inhibitors.
4-(Arylthio)-pyridin-2(1H)-ones variously substituted in their 3-, 5-, and 6-positions have been synthesized as a new series of 1… 
1993
1993
Inhibition of HIV-1 reverse transcriptase by pyridinone derivatives. Potency, binding characteristics, and effect of template sequence.
Highly Cited
1992
Highly Cited
1992
Functional analysis of HIV-1 reverse transcriptase amino acids involved in resistance to multiple nonnucleoside inhibitors.
Highly Cited
1992
Highly Cited
1992
Identification of the human immunodeficiency virus reverse transcriptase residues that contribute to the activity of diverse nonnucleoside inhibitors
The reverse transcriptase (RT) of human immunodeficiency virus type 1 (HIV-1) is potently inhibited by a structurally diverse… 
Highly Cited
1973
Highly Cited
1973
Purification and properties of the aldehyde oxidases from hog and rabbit livers.
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