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nitecapone

Known as: 3-(3,4-dihydroxy-5-nitrobenzylidine)-2,4-pentanedione 
 
National Institutes of Health

Papers overview

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Highly Cited
2002
Highly Cited
2002
BACKGROUND Levels of advanced glycation end products (AGE) are elevated in individuals with advancing age, renal failure, and… Expand
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Review
2001
Review
2001
Free radicals and other so-called ‘reactive species’ are constantly produced in the brain in vivo. Some arise by ‘accidents of… Expand
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Highly Cited
2001
Highly Cited
2001
We attempted to characterize a spinal neuronal correlate of painful neuropathy induced by diabetes mellitus (DM). Pain behavior… Expand
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Review
1999
Review
1999
[Axelrod et al. (1958)][1] first described the enzyme-catalyzed O- methylation of catecholamines and other catechols in the late… Expand
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Review
1997
Review
1997
A book originating from an annual meeting of the Oxygen Society (Charleston, South Carolina, 1995) [7] and dedicated to Paul… Expand
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1997
1997
The enzyme catechol-O-methyltransferase (COMT), which plays an important role for dopamine metabolism, is abundantly expressed in… Expand
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Review
1994
Review
1994
1. The structure of catechol O-methyltransferase (COMT) has been recently characterized and a series of new and selective COMT… Expand
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1992
1992
PET studies were performed to investigate the effects of a new catechol-O-methyltransferase (COMT) inhibitor, nitecapone (OR-462… Expand
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1991
1991
SummaryThe effect of increasing single oral doses of the novel catechol-O-methyltransferase (COMT) inhibitor, nitecapone, on… Expand
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1990
1990
A new catechol-O-methyltransferase (COMT) inhibitor, nitecapone, was given in increasing doses of 0-100 mg concomitantly with L… Expand
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