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OR 462

Known as: OR-462, OR462 
National Institutes of Health

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nitecapone

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1999
1999
Study of DT-diaphorase in pigment-producing cells.
DT-diaphorase is an FAD-containing enzyme capable of a two-electron reduction of ortho- and paraquinones. Nicotinamide coenzymes… 
1998
1998
Effect of catechol‐O‐methyltransferase inhibition on brain uptake of [18F]fluorodopa: Implications for compartmental modelling and clinical usefulness
The efficacy of levo‐DOPA in the treatment of Parkinson's disease is potentiated by blockade of its peripheral metabolism with… 
1994
1994
3-O-Methyl-DOPA is not involved in the development of behavioral supersensitivity after repeated l-DOPA administration in 6-OHDA lesioned rats
1992
1992
Effect of nitecapone and clorgyline, given intracerebro-ventricularly on L-dopa metabolism in the rat brain.
A new COMT inhibitor, nitecapone (OR-462) or clorgyline, a MAO-A inhibitor, was infused into the 3rd brain ventricle (i.c.v.) of… 
1991
1991
Effect of high single doses of levodopa and carbidopa on brain dopamine and its metabolites: modulation by selective inhibitors of monoamine oxidase and/or catechol-O-methyltransferase in the male…
SummaryThe upper limits of striatal and hypothalamic dopamine formation and metabolism in the rat were defined after acute… 
1990
1990
Effect of nitecapone (OR-462) on the pharmacokinetics of levodopa and 3-O-methyldopa formation in cynomolgus monkeys.
3-O-Methyldopa (OMD) is the principal circulating metabolite formed from exogenously administered levodopa. We studied the effect… 
1990
1990
L-dopa as substrate for human duodenal catechol-O-methyltransferase and aromatic L-amino acid decarboxylase.
Catechol-O-methyltransferase (COMT) and aromatic L-amino acid decarboxylase (AADC) activities were determined in human… 
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